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Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies

Bilirubin is an important antioxidant and a modulator of biological functions. However, most of the protection against oxidative stress was shown in vitro or ex vivo. The aim of this case-control study was to investigate whether subjects with Gilbert’s syndrome (GS) experience different levels of li...

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Autores principales: Wagner, Karl-Heinz, Khoei, Nazlisadat Seyed, Hana, Claudia Anna, Doberer, Daniel, Marculescu, Rodrig, Bulmer, Andrew Cameron, Hörmann-Wallner, Marlies, Mölzer, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472792/
https://www.ncbi.nlm.nih.gov/pubmed/34573106
http://dx.doi.org/10.3390/antiox10091474
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author Wagner, Karl-Heinz
Khoei, Nazlisadat Seyed
Hana, Claudia Anna
Doberer, Daniel
Marculescu, Rodrig
Bulmer, Andrew Cameron
Hörmann-Wallner, Marlies
Mölzer, Christine
author_facet Wagner, Karl-Heinz
Khoei, Nazlisadat Seyed
Hana, Claudia Anna
Doberer, Daniel
Marculescu, Rodrig
Bulmer, Andrew Cameron
Hörmann-Wallner, Marlies
Mölzer, Christine
author_sort Wagner, Karl-Heinz
collection PubMed
description Bilirubin is an important antioxidant and a modulator of biological functions. However, most of the protection against oxidative stress was shown in vitro or ex vivo. The aim of this case-control study was to investigate whether subjects with Gilbert’s syndrome (GS) experience different levels of lipid and protein oxidation (as well as differences in oxidative stress related markers) compared to healthy controls. GS subjects (n = 119) demonstrated higher serum levels of unconjugated bilirubin (p < 0.001), a lower BMI (p < 0.001), 37% higher antioxidant potential assessed as ferric reducing ability potential (p < 0.001), higher advanced oxidation protein products (p < 0.01) andlower apolipoprotein B (p < 0.05), hs-C-reactive protein (p < 0.05), interleukin 6 (p < 0.001) and interleukin 1 beta (p < 0.05) values compared to healthy controls (n = 119). Furthermore, the resting heart rate was significantly lower in the GS group (p < 0.05). Stronger protective effects for GS subjects were demonstrated in the older subgroup (n = 104, average age 50 years) compared to those of the younger group (n = 134, average age 27 years). Although not all markers related to oxidative stress were different between the groups (e.g., malondialdehyde, homocysteine, oxLDL, and myeloperoxidase; p > 0.05), the observed differences contribute to the explanation of why GS serves as an important protector in the pathogenesis of metabolic, oxidative stress related diseases.
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spelling pubmed-84727922021-09-28 Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies Wagner, Karl-Heinz Khoei, Nazlisadat Seyed Hana, Claudia Anna Doberer, Daniel Marculescu, Rodrig Bulmer, Andrew Cameron Hörmann-Wallner, Marlies Mölzer, Christine Antioxidants (Basel) Article Bilirubin is an important antioxidant and a modulator of biological functions. However, most of the protection against oxidative stress was shown in vitro or ex vivo. The aim of this case-control study was to investigate whether subjects with Gilbert’s syndrome (GS) experience different levels of lipid and protein oxidation (as well as differences in oxidative stress related markers) compared to healthy controls. GS subjects (n = 119) demonstrated higher serum levels of unconjugated bilirubin (p < 0.001), a lower BMI (p < 0.001), 37% higher antioxidant potential assessed as ferric reducing ability potential (p < 0.001), higher advanced oxidation protein products (p < 0.01) andlower apolipoprotein B (p < 0.05), hs-C-reactive protein (p < 0.05), interleukin 6 (p < 0.001) and interleukin 1 beta (p < 0.05) values compared to healthy controls (n = 119). Furthermore, the resting heart rate was significantly lower in the GS group (p < 0.05). Stronger protective effects for GS subjects were demonstrated in the older subgroup (n = 104, average age 50 years) compared to those of the younger group (n = 134, average age 27 years). Although not all markers related to oxidative stress were different between the groups (e.g., malondialdehyde, homocysteine, oxLDL, and myeloperoxidase; p > 0.05), the observed differences contribute to the explanation of why GS serves as an important protector in the pathogenesis of metabolic, oxidative stress related diseases. MDPI 2021-09-15 /pmc/articles/PMC8472792/ /pubmed/34573106 http://dx.doi.org/10.3390/antiox10091474 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wagner, Karl-Heinz
Khoei, Nazlisadat Seyed
Hana, Claudia Anna
Doberer, Daniel
Marculescu, Rodrig
Bulmer, Andrew Cameron
Hörmann-Wallner, Marlies
Mölzer, Christine
Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies
title Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies
title_full Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies
title_fullStr Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies
title_full_unstemmed Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies
title_short Oxidative Stress and Related Biomarkers in Gilbert’s Syndrome: A Secondary Analysis of Two Case-Control Studies
title_sort oxidative stress and related biomarkers in gilbert’s syndrome: a secondary analysis of two case-control studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472792/
https://www.ncbi.nlm.nih.gov/pubmed/34573106
http://dx.doi.org/10.3390/antiox10091474
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