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Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study

The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment (MCI), and AD dementia in mild and moderate s...

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Autores principales: Tsatali, Marianna, Moraitou, Despina, Poptsi, Eleni, Sia, Eleni, Agogiatou, Christina, Gialaouzidis, Moses, Tabakis, Irene-Maria, Avdikou, Konstantina, Bakoglidou, Evaggelia, Batsila, Georgia, Bekiaridis-Moschou, Dimitrios, Chatziroumpi, Ourania, Diamantidou, Alexandra, Gavra, Andromachi, Kouroundi, Eleni, Liapi, Despina, Markou, Nefeli, Ouzouni, Fani, Papasozomenou, Chrysa, Soumpourou, Aikaterini, Tsolaki, Magdalini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472805/
https://www.ncbi.nlm.nih.gov/pubmed/34573186
http://dx.doi.org/10.3390/brainsci11091165
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author Tsatali, Marianna
Moraitou, Despina
Poptsi, Eleni
Sia, Eleni
Agogiatou, Christina
Gialaouzidis, Moses
Tabakis, Irene-Maria
Avdikou, Konstantina
Bakoglidou, Evaggelia
Batsila, Georgia
Bekiaridis-Moschou, Dimitrios
Chatziroumpi, Ourania
Diamantidou, Alexandra
Gavra, Andromachi
Kouroundi, Eleni
Liapi, Despina
Markou, Nefeli
Ouzouni, Fani
Papasozomenou, Chrysa
Soumpourou, Aikaterini
Tsolaki, Magdalini
author_facet Tsatali, Marianna
Moraitou, Despina
Poptsi, Eleni
Sia, Eleni
Agogiatou, Christina
Gialaouzidis, Moses
Tabakis, Irene-Maria
Avdikou, Konstantina
Bakoglidou, Evaggelia
Batsila, Georgia
Bekiaridis-Moschou, Dimitrios
Chatziroumpi, Ourania
Diamantidou, Alexandra
Gavra, Andromachi
Kouroundi, Eleni
Liapi, Despina
Markou, Nefeli
Ouzouni, Fani
Papasozomenou, Chrysa
Soumpourou, Aikaterini
Tsolaki, Magdalini
author_sort Tsatali, Marianna
collection PubMed
description The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment (MCI), and AD dementia in mild and moderate stages. Method: 407 older adults, diagnosed either with MCI or AD dementia (ADD), were recruited from the Day Centers of the Greek Association of Alzheimer Disease and Related Disorders (GAADRD). Neuropsychological assessment was performed at baseline (at the time of diagnosis) between May and July of 2018, as well as for two consecutive follow-up assessments, identical in period, in 2019 and 2020. The majority of participants had participated in non-pharmacological interventions during 2018 as well as 2019, whereas all of them continued their participation online in 2020. Results: Mixed measures analysis of variance showed that participants’ ‘deterioration difference—D’ by means of their performance difference in neuropsychological assessments between 2018–2019 (D1) and 2019–2020 (D2) did not change, except for the FUCAS, RAVLT, and phonemic fluency tests, since both groups resulted in a larger deterioration difference (D2) in these tests. Additionally, three path models examining the direct relationships between performance in tests measuring mood, as well as everyday functioning and cognitive measures, showed that participants’ worsened performance in the 2019 and 2020 assessments was strongly affected by NPI performance, in sharp contrast to the 2018 assessment. Discussion: During the lockdown period, MCI and ADD patients’ neuropsychological performance did not change, except from the tests measuring verbal memory, learning, and phonemic fluency, as well as everyday functioning. However, the natural progression of the MCI as well as ADD condition is the main reason for participants’ deterioration. Mood performance became increasingly closely related to cognition and everyday functioning. Hence, the role of quarantine and AD progression are discussed as potential factors associated with impairments.
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spelling pubmed-84728052021-09-28 Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study Tsatali, Marianna Moraitou, Despina Poptsi, Eleni Sia, Eleni Agogiatou, Christina Gialaouzidis, Moses Tabakis, Irene-Maria Avdikou, Konstantina Bakoglidou, Evaggelia Batsila, Georgia Bekiaridis-Moschou, Dimitrios Chatziroumpi, Ourania Diamantidou, Alexandra Gavra, Andromachi Kouroundi, Eleni Liapi, Despina Markou, Nefeli Ouzouni, Fani Papasozomenou, Chrysa Soumpourou, Aikaterini Tsolaki, Magdalini Brain Sci Article The aim of the study was to examine potential cognitive, mood (depression and anxiety) and behavioral changes that may be related to the quarantine and the lockdown applied during the COVID-19 pandemic in Greek older adults with mild cognitive impairment (MCI), and AD dementia in mild and moderate stages. Method: 407 older adults, diagnosed either with MCI or AD dementia (ADD), were recruited from the Day Centers of the Greek Association of Alzheimer Disease and Related Disorders (GAADRD). Neuropsychological assessment was performed at baseline (at the time of diagnosis) between May and July of 2018, as well as for two consecutive follow-up assessments, identical in period, in 2019 and 2020. The majority of participants had participated in non-pharmacological interventions during 2018 as well as 2019, whereas all of them continued their participation online in 2020. Results: Mixed measures analysis of variance showed that participants’ ‘deterioration difference—D’ by means of their performance difference in neuropsychological assessments between 2018–2019 (D1) and 2019–2020 (D2) did not change, except for the FUCAS, RAVLT, and phonemic fluency tests, since both groups resulted in a larger deterioration difference (D2) in these tests. Additionally, three path models examining the direct relationships between performance in tests measuring mood, as well as everyday functioning and cognitive measures, showed that participants’ worsened performance in the 2019 and 2020 assessments was strongly affected by NPI performance, in sharp contrast to the 2018 assessment. Discussion: During the lockdown period, MCI and ADD patients’ neuropsychological performance did not change, except from the tests measuring verbal memory, learning, and phonemic fluency, as well as everyday functioning. However, the natural progression of the MCI as well as ADD condition is the main reason for participants’ deterioration. Mood performance became increasingly closely related to cognition and everyday functioning. Hence, the role of quarantine and AD progression are discussed as potential factors associated with impairments. MDPI 2021-08-31 /pmc/articles/PMC8472805/ /pubmed/34573186 http://dx.doi.org/10.3390/brainsci11091165 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsatali, Marianna
Moraitou, Despina
Poptsi, Eleni
Sia, Eleni
Agogiatou, Christina
Gialaouzidis, Moses
Tabakis, Irene-Maria
Avdikou, Konstantina
Bakoglidou, Evaggelia
Batsila, Georgia
Bekiaridis-Moschou, Dimitrios
Chatziroumpi, Ourania
Diamantidou, Alexandra
Gavra, Andromachi
Kouroundi, Eleni
Liapi, Despina
Markou, Nefeli
Ouzouni, Fani
Papasozomenou, Chrysa
Soumpourou, Aikaterini
Tsolaki, Magdalini
Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study
title Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study
title_full Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study
title_fullStr Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study
title_full_unstemmed Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study
title_short Are There Any Cognitive and Behavioral Changes Potentially Related to Quarantine Due to the COVID-19 Pandemic in People with Mild Cognitive Impairment and AD Dementia? A Longitudinal Study
title_sort are there any cognitive and behavioral changes potentially related to quarantine due to the covid-19 pandemic in people with mild cognitive impairment and ad dementia? a longitudinal study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472805/
https://www.ncbi.nlm.nih.gov/pubmed/34573186
http://dx.doi.org/10.3390/brainsci11091165
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