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Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses
To date, no evidence supports the fact that animals play a role in the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19). However, several animal species are naturally susceptible to SARS-CoV-2...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472846/ https://www.ncbi.nlm.nih.gov/pubmed/34578266 http://dx.doi.org/10.3390/v13091683 |
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author | Fernández-Bellon, Hugo Rodon, Jordi Fernández-Bastit, Leira Almagro, Vanessa Padilla-Solé, Pilar Lorca-Oró, Cristina Valle, Rosa Roca, Núria Grazioli, Santina Trogu, Tiziana Bensaid, Albert Carrillo, Jorge Izquierdo-Useros, Nuria Blanco, Julià Parera, Mariona Noguera-Julián, Marc Clotet, Bonaventura Moreno, Ana Segalés, Joaquim Vergara-Alert, Júlia |
author_facet | Fernández-Bellon, Hugo Rodon, Jordi Fernández-Bastit, Leira Almagro, Vanessa Padilla-Solé, Pilar Lorca-Oró, Cristina Valle, Rosa Roca, Núria Grazioli, Santina Trogu, Tiziana Bensaid, Albert Carrillo, Jorge Izquierdo-Useros, Nuria Blanco, Julià Parera, Mariona Noguera-Julián, Marc Clotet, Bonaventura Moreno, Ana Segalés, Joaquim Vergara-Alert, Júlia |
author_sort | Fernández-Bellon, Hugo |
collection | PubMed |
description | To date, no evidence supports the fact that animals play a role in the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19). However, several animal species are naturally susceptible to SARS-CoV-2 infection. Besides pets (cats, dogs, Syrian hamsters, and ferrets) and farm animals (minks), different zoo animal species have tested positive for SARS-CoV-2 (large felids and non-human primates). After the summer of 2020, a second wave of SARS-CoV-2 infection occurred in Barcelona (Spain), reaching a peak of positive cases in November. During that period, four lions (Panthera leo) at the Barcelona Zoo and three caretakers developed respiratory signs and tested positive for the SARS-CoV-2 antigen. Lion infection was monitored for several weeks and nasal, fecal, saliva, and blood samples were taken at different time-points. SARS-CoV-2 RNA was detected in nasal samples from all studied lions and the viral RNA was detected up to two weeks after the initial viral positive test in three out of four animals. The SARS-CoV-2 genome was also detected in the feces of animals at different times. Virus isolation was successful only from respiratory samples of two lions at an early time-point. The four animals developed neutralizing antibodies after the infection that were detectable four months after the initial diagnosis. The partial SARS-CoV-2 genome sequence from one animal caretaker was identical to the sequences obtained from lions. Chronology of the events, the viral dynamics, and the genomic data support human-to-lion transmission as the origin of infection. |
format | Online Article Text |
id | pubmed-8472846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84728462021-09-28 Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses Fernández-Bellon, Hugo Rodon, Jordi Fernández-Bastit, Leira Almagro, Vanessa Padilla-Solé, Pilar Lorca-Oró, Cristina Valle, Rosa Roca, Núria Grazioli, Santina Trogu, Tiziana Bensaid, Albert Carrillo, Jorge Izquierdo-Useros, Nuria Blanco, Julià Parera, Mariona Noguera-Julián, Marc Clotet, Bonaventura Moreno, Ana Segalés, Joaquim Vergara-Alert, Júlia Viruses Article To date, no evidence supports the fact that animals play a role in the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19). However, several animal species are naturally susceptible to SARS-CoV-2 infection. Besides pets (cats, dogs, Syrian hamsters, and ferrets) and farm animals (minks), different zoo animal species have tested positive for SARS-CoV-2 (large felids and non-human primates). After the summer of 2020, a second wave of SARS-CoV-2 infection occurred in Barcelona (Spain), reaching a peak of positive cases in November. During that period, four lions (Panthera leo) at the Barcelona Zoo and three caretakers developed respiratory signs and tested positive for the SARS-CoV-2 antigen. Lion infection was monitored for several weeks and nasal, fecal, saliva, and blood samples were taken at different time-points. SARS-CoV-2 RNA was detected in nasal samples from all studied lions and the viral RNA was detected up to two weeks after the initial viral positive test in three out of four animals. The SARS-CoV-2 genome was also detected in the feces of animals at different times. Virus isolation was successful only from respiratory samples of two lions at an early time-point. The four animals developed neutralizing antibodies after the infection that were detectable four months after the initial diagnosis. The partial SARS-CoV-2 genome sequence from one animal caretaker was identical to the sequences obtained from lions. Chronology of the events, the viral dynamics, and the genomic data support human-to-lion transmission as the origin of infection. MDPI 2021-08-25 /pmc/articles/PMC8472846/ /pubmed/34578266 http://dx.doi.org/10.3390/v13091683 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fernández-Bellon, Hugo Rodon, Jordi Fernández-Bastit, Leira Almagro, Vanessa Padilla-Solé, Pilar Lorca-Oró, Cristina Valle, Rosa Roca, Núria Grazioli, Santina Trogu, Tiziana Bensaid, Albert Carrillo, Jorge Izquierdo-Useros, Nuria Blanco, Julià Parera, Mariona Noguera-Julián, Marc Clotet, Bonaventura Moreno, Ana Segalés, Joaquim Vergara-Alert, Júlia Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses |
title | Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses |
title_full | Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses |
title_fullStr | Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses |
title_full_unstemmed | Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses |
title_short | Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses |
title_sort | monitoring natural sars-cov-2 infection in lions (panthera leo) at the barcelona zoo: viral dynamics and host responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472846/ https://www.ncbi.nlm.nih.gov/pubmed/34578266 http://dx.doi.org/10.3390/v13091683 |
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