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The History of Pertussis Toxin

Besides the typical whooping cough syndrome, infection with Bordetella pertussis or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection against disease. Initi...

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Autores principales: Locht, Camille, Antoine, Rudy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472871/
https://www.ncbi.nlm.nih.gov/pubmed/34564627
http://dx.doi.org/10.3390/toxins13090623
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author Locht, Camille
Antoine, Rudy
author_facet Locht, Camille
Antoine, Rudy
author_sort Locht, Camille
collection PubMed
description Besides the typical whooping cough syndrome, infection with Bordetella pertussis or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection against disease. Initially believed to be associated with different molecular entities, decades of research have provided the demonstration that these activities are all due to a single molecule today referred to as pertussis toxin. The three-dimensional structure and molecular mechanisms of pertussis toxin action, as well as its role in protective immunity have been uncovered in the last 50 years. In this article, we review the history of pertussis toxin, including the paradigm shift that occurred in the 1980s which established the pertussis toxin as a single molecule. We describe the role molecular biology played in the understanding of pertussis toxin action, its role as a molecular tool in cell biology and as a protective antigen in acellular pertussis vaccines and possibly new-generation vaccines, as well as potential therapeutical applications.
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spelling pubmed-84728712021-09-28 The History of Pertussis Toxin Locht, Camille Antoine, Rudy Toxins (Basel) Review Besides the typical whooping cough syndrome, infection with Bordetella pertussis or immunization with whole-cell vaccines can result in a wide variety of physiological manifestations, including leukocytosis, hyper-insulinemia, and histamine sensitization, as well as protection against disease. Initially believed to be associated with different molecular entities, decades of research have provided the demonstration that these activities are all due to a single molecule today referred to as pertussis toxin. The three-dimensional structure and molecular mechanisms of pertussis toxin action, as well as its role in protective immunity have been uncovered in the last 50 years. In this article, we review the history of pertussis toxin, including the paradigm shift that occurred in the 1980s which established the pertussis toxin as a single molecule. We describe the role molecular biology played in the understanding of pertussis toxin action, its role as a molecular tool in cell biology and as a protective antigen in acellular pertussis vaccines and possibly new-generation vaccines, as well as potential therapeutical applications. MDPI 2021-09-05 /pmc/articles/PMC8472871/ /pubmed/34564627 http://dx.doi.org/10.3390/toxins13090623 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Locht, Camille
Antoine, Rudy
The History of Pertussis Toxin
title The History of Pertussis Toxin
title_full The History of Pertussis Toxin
title_fullStr The History of Pertussis Toxin
title_full_unstemmed The History of Pertussis Toxin
title_short The History of Pertussis Toxin
title_sort history of pertussis toxin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472871/
https://www.ncbi.nlm.nih.gov/pubmed/34564627
http://dx.doi.org/10.3390/toxins13090623
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