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Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults
Human Adenoviruses (HAdV) are known to be potentially associated with strong inflammatory responses and morbidity in pediatric patients. Although most of the primary infections are self-limiting, the severity of clinical presentation, the elevation of the white blood cell count and inflammatory mark...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472906/ https://www.ncbi.nlm.nih.gov/pubmed/34578465 http://dx.doi.org/10.3390/v13091885 |
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author | Biserni, Giovanni Battista Scarpini, Sara Dondi, Arianna Biagi, Carlotta Pierantoni, Luca Masetti, Riccardo Sureshkumar, Sugitha Rocca, Alessandro Lanari, Marcello |
author_facet | Biserni, Giovanni Battista Scarpini, Sara Dondi, Arianna Biagi, Carlotta Pierantoni, Luca Masetti, Riccardo Sureshkumar, Sugitha Rocca, Alessandro Lanari, Marcello |
author_sort | Biserni, Giovanni Battista |
collection | PubMed |
description | Human Adenoviruses (HAdV) are known to be potentially associated with strong inflammatory responses and morbidity in pediatric patients. Although most of the primary infections are self-limiting, the severity of clinical presentation, the elevation of the white blood cell count and inflammatory markers often mimic a bacterial infection and lead to an inappropriate use of antibiotics. In infections caused by HAdV, rapid antigen detection kits are advisable but not employed routinely; costs and feasibility of rapid syndromic molecular diagnosis may limit its use in the in-hospital setting; lymphocyte cultures and two-sampled serology are time consuming and impractical when considering the use of antibiotics. In this review, we aim to describe the principal diagnostic tools and the immune response in HAdV infections and evaluate whether markers based on the response of the host may help early recognition of HAdV and avoid inappropriate antimicrobial prescriptions in acute airway infections. |
format | Online Article Text |
id | pubmed-8472906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84729062021-09-28 Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults Biserni, Giovanni Battista Scarpini, Sara Dondi, Arianna Biagi, Carlotta Pierantoni, Luca Masetti, Riccardo Sureshkumar, Sugitha Rocca, Alessandro Lanari, Marcello Viruses Review Human Adenoviruses (HAdV) are known to be potentially associated with strong inflammatory responses and morbidity in pediatric patients. Although most of the primary infections are self-limiting, the severity of clinical presentation, the elevation of the white blood cell count and inflammatory markers often mimic a bacterial infection and lead to an inappropriate use of antibiotics. In infections caused by HAdV, rapid antigen detection kits are advisable but not employed routinely; costs and feasibility of rapid syndromic molecular diagnosis may limit its use in the in-hospital setting; lymphocyte cultures and two-sampled serology are time consuming and impractical when considering the use of antibiotics. In this review, we aim to describe the principal diagnostic tools and the immune response in HAdV infections and evaluate whether markers based on the response of the host may help early recognition of HAdV and avoid inappropriate antimicrobial prescriptions in acute airway infections. MDPI 2021-09-21 /pmc/articles/PMC8472906/ /pubmed/34578465 http://dx.doi.org/10.3390/v13091885 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Biserni, Giovanni Battista Scarpini, Sara Dondi, Arianna Biagi, Carlotta Pierantoni, Luca Masetti, Riccardo Sureshkumar, Sugitha Rocca, Alessandro Lanari, Marcello Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults |
title | Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults |
title_full | Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults |
title_fullStr | Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults |
title_full_unstemmed | Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults |
title_short | Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults |
title_sort | potential diagnostic and prognostic biomarkers for adenovirus respiratory infection in children and young adults |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472906/ https://www.ncbi.nlm.nih.gov/pubmed/34578465 http://dx.doi.org/10.3390/v13091885 |
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