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Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon

Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availabil...

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Autores principales: Nyborg, Christoffer, Bonnevie-Svendsen, Martin, Melsom, Helene Støle, Melau, Jørgen, Seljeflot, Ingebjørg, Hisdal, Jonny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472968/
https://www.ncbi.nlm.nih.gov/pubmed/34564325
http://dx.doi.org/10.3390/sports9090120
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author Nyborg, Christoffer
Bonnevie-Svendsen, Martin
Melsom, Helene Støle
Melau, Jørgen
Seljeflot, Ingebjørg
Hisdal, Jonny
author_facet Nyborg, Christoffer
Bonnevie-Svendsen, Martin
Melsom, Helene Støle
Melau, Jørgen
Seljeflot, Ingebjørg
Hisdal, Jonny
author_sort Nyborg, Christoffer
collection PubMed
description Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availability intracellularly through competing for transport over the cellular membrane. To study the NO synthesis after prolonged exercise, we assessed circulatory L-arginine, the L-arginine/ADMA ratio, and SDMA before, after, and on the day after the Norseman Xtreme triathlon, an Ironman distance triathlon. We found significantly reduced levels of L-arginine and the L-arginine/ADMA ratio and increased levels of SDMA after the race (all p < 0.05). L-arginine rose toward baseline levels the day after the race, but ADMA increased beyond baseline levels, and SDMA remained above baseline the day after the race. The reduced levels of L-arginine and the L-arginine/ADMA ratio, and increased SDMA, after the race indicate a state of reduced capability of NO production. Increased levels of ADMA and SDMA, and reduced L-arginine/ADMA ratio, as seen the day after the race, are known risk markers of atherosclerosis and warrant further studies.
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spelling pubmed-84729682021-09-28 Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon Nyborg, Christoffer Bonnevie-Svendsen, Martin Melsom, Helene Støle Melau, Jørgen Seljeflot, Ingebjørg Hisdal, Jonny Sports (Basel) Article Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availability intracellularly through competing for transport over the cellular membrane. To study the NO synthesis after prolonged exercise, we assessed circulatory L-arginine, the L-arginine/ADMA ratio, and SDMA before, after, and on the day after the Norseman Xtreme triathlon, an Ironman distance triathlon. We found significantly reduced levels of L-arginine and the L-arginine/ADMA ratio and increased levels of SDMA after the race (all p < 0.05). L-arginine rose toward baseline levels the day after the race, but ADMA increased beyond baseline levels, and SDMA remained above baseline the day after the race. The reduced levels of L-arginine and the L-arginine/ADMA ratio, and increased SDMA, after the race indicate a state of reduced capability of NO production. Increased levels of ADMA and SDMA, and reduced L-arginine/ADMA ratio, as seen the day after the race, are known risk markers of atherosclerosis and warrant further studies. MDPI 2021-08-31 /pmc/articles/PMC8472968/ /pubmed/34564325 http://dx.doi.org/10.3390/sports9090120 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nyborg, Christoffer
Bonnevie-Svendsen, Martin
Melsom, Helene Støle
Melau, Jørgen
Seljeflot, Ingebjørg
Hisdal, Jonny
Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
title Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
title_full Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
title_fullStr Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
title_full_unstemmed Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
title_short Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
title_sort reduced l-arginine and l-arginine-adma-ratio, and increased sdma after norseman xtreme triathlon
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472968/
https://www.ncbi.nlm.nih.gov/pubmed/34564325
http://dx.doi.org/10.3390/sports9090120
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