Cargando…

Cytokine Response to SARS-CoV-2 Infection in Children

The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity o...

Descripción completa

Detalles Bibliográficos
Autores principales: Curatola, Antonietta, Chiaretti, Antonio, Ferretti, Serena, Bersani, Giulia, Lucchetti, Donatella, Capossela, Lavinia, Sgambato, Alessandro, Gatto, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473005/
https://www.ncbi.nlm.nih.gov/pubmed/34578450
http://dx.doi.org/10.3390/v13091868
_version_ 1784574879904825344
author Curatola, Antonietta
Chiaretti, Antonio
Ferretti, Serena
Bersani, Giulia
Lucchetti, Donatella
Capossela, Lavinia
Sgambato, Alessandro
Gatto, Antonio
author_facet Curatola, Antonietta
Chiaretti, Antonio
Ferretti, Serena
Bersani, Giulia
Lucchetti, Donatella
Capossela, Lavinia
Sgambato, Alessandro
Gatto, Antonio
author_sort Curatola, Antonietta
collection PubMed
description The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity of COVID-19. All children (aged 0−18) admitted to the Pediatric Emergency Department and tested with nasopharyngeal swab for SARS-CoV-2 were recruited and assigned to three groups: COVID-19, other infections, control group. Clinical and laboratory data of these patients, including circulating cytokine levels, were analyzed in three groups. Fever was the most frequent symptom in COVID-19 (67.3%). Neutropenia was found in the COVID-19 group (p < 0.05); no difference was observed for lymphocyte counts in the three groups. Higher levels of IL-6 and TNF-alpha were found in the COVID-19 group compared to other infections and control groups (p = 0.014 and p = 0.001, respectively). Whereas, in the COVID-19 group, no difference was observed as for the same cytokines among sub-groups of different disease severity (p = 0.7 and p = 0.8). Serum levels of IL-6 and TNF-alpha were higher in COVID-19 children than in children with other infectious diseases, but those levels did not correlate with disease severity. Clinical studies in a large pediatric population are necessary to better define the role of the immune-mediated response in SARS-CoV-2 infections in children.
format Online
Article
Text
id pubmed-8473005
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84730052021-09-28 Cytokine Response to SARS-CoV-2 Infection in Children Curatola, Antonietta Chiaretti, Antonio Ferretti, Serena Bersani, Giulia Lucchetti, Donatella Capossela, Lavinia Sgambato, Alessandro Gatto, Antonio Viruses Article The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity of COVID-19. All children (aged 0−18) admitted to the Pediatric Emergency Department and tested with nasopharyngeal swab for SARS-CoV-2 were recruited and assigned to three groups: COVID-19, other infections, control group. Clinical and laboratory data of these patients, including circulating cytokine levels, were analyzed in three groups. Fever was the most frequent symptom in COVID-19 (67.3%). Neutropenia was found in the COVID-19 group (p < 0.05); no difference was observed for lymphocyte counts in the three groups. Higher levels of IL-6 and TNF-alpha were found in the COVID-19 group compared to other infections and control groups (p = 0.014 and p = 0.001, respectively). Whereas, in the COVID-19 group, no difference was observed as for the same cytokines among sub-groups of different disease severity (p = 0.7 and p = 0.8). Serum levels of IL-6 and TNF-alpha were higher in COVID-19 children than in children with other infectious diseases, but those levels did not correlate with disease severity. Clinical studies in a large pediatric population are necessary to better define the role of the immune-mediated response in SARS-CoV-2 infections in children. MDPI 2021-09-18 /pmc/articles/PMC8473005/ /pubmed/34578450 http://dx.doi.org/10.3390/v13091868 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Curatola, Antonietta
Chiaretti, Antonio
Ferretti, Serena
Bersani, Giulia
Lucchetti, Donatella
Capossela, Lavinia
Sgambato, Alessandro
Gatto, Antonio
Cytokine Response to SARS-CoV-2 Infection in Children
title Cytokine Response to SARS-CoV-2 Infection in Children
title_full Cytokine Response to SARS-CoV-2 Infection in Children
title_fullStr Cytokine Response to SARS-CoV-2 Infection in Children
title_full_unstemmed Cytokine Response to SARS-CoV-2 Infection in Children
title_short Cytokine Response to SARS-CoV-2 Infection in Children
title_sort cytokine response to sars-cov-2 infection in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473005/
https://www.ncbi.nlm.nih.gov/pubmed/34578450
http://dx.doi.org/10.3390/v13091868
work_keys_str_mv AT curatolaantonietta cytokineresponsetosarscov2infectioninchildren
AT chiarettiantonio cytokineresponsetosarscov2infectioninchildren
AT ferrettiserena cytokineresponsetosarscov2infectioninchildren
AT bersanigiulia cytokineresponsetosarscov2infectioninchildren
AT lucchettidonatella cytokineresponsetosarscov2infectioninchildren
AT caposselalavinia cytokineresponsetosarscov2infectioninchildren
AT sgambatoalessandro cytokineresponsetosarscov2infectioninchildren
AT gattoantonio cytokineresponsetosarscov2infectioninchildren