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Cytokine Response to SARS-CoV-2 Infection in Children
The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473005/ https://www.ncbi.nlm.nih.gov/pubmed/34578450 http://dx.doi.org/10.3390/v13091868 |
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author | Curatola, Antonietta Chiaretti, Antonio Ferretti, Serena Bersani, Giulia Lucchetti, Donatella Capossela, Lavinia Sgambato, Alessandro Gatto, Antonio |
author_facet | Curatola, Antonietta Chiaretti, Antonio Ferretti, Serena Bersani, Giulia Lucchetti, Donatella Capossela, Lavinia Sgambato, Alessandro Gatto, Antonio |
author_sort | Curatola, Antonietta |
collection | PubMed |
description | The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity of COVID-19. All children (aged 0−18) admitted to the Pediatric Emergency Department and tested with nasopharyngeal swab for SARS-CoV-2 were recruited and assigned to three groups: COVID-19, other infections, control group. Clinical and laboratory data of these patients, including circulating cytokine levels, were analyzed in three groups. Fever was the most frequent symptom in COVID-19 (67.3%). Neutropenia was found in the COVID-19 group (p < 0.05); no difference was observed for lymphocyte counts in the three groups. Higher levels of IL-6 and TNF-alpha were found in the COVID-19 group compared to other infections and control groups (p = 0.014 and p = 0.001, respectively). Whereas, in the COVID-19 group, no difference was observed as for the same cytokines among sub-groups of different disease severity (p = 0.7 and p = 0.8). Serum levels of IL-6 and TNF-alpha were higher in COVID-19 children than in children with other infectious diseases, but those levels did not correlate with disease severity. Clinical studies in a large pediatric population are necessary to better define the role of the immune-mediated response in SARS-CoV-2 infections in children. |
format | Online Article Text |
id | pubmed-8473005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84730052021-09-28 Cytokine Response to SARS-CoV-2 Infection in Children Curatola, Antonietta Chiaretti, Antonio Ferretti, Serena Bersani, Giulia Lucchetti, Donatella Capossela, Lavinia Sgambato, Alessandro Gatto, Antonio Viruses Article The causal connection between serum biomarkers and COVID-19 severity or pathogenicity in children is unclear. The aim of this study was to describe clinical and immunological features of children affected by COVID-19. The secondary aim was to evaluate whether these cytokines could predict severity of COVID-19. All children (aged 0−18) admitted to the Pediatric Emergency Department and tested with nasopharyngeal swab for SARS-CoV-2 were recruited and assigned to three groups: COVID-19, other infections, control group. Clinical and laboratory data of these patients, including circulating cytokine levels, were analyzed in three groups. Fever was the most frequent symptom in COVID-19 (67.3%). Neutropenia was found in the COVID-19 group (p < 0.05); no difference was observed for lymphocyte counts in the three groups. Higher levels of IL-6 and TNF-alpha were found in the COVID-19 group compared to other infections and control groups (p = 0.014 and p = 0.001, respectively). Whereas, in the COVID-19 group, no difference was observed as for the same cytokines among sub-groups of different disease severity (p = 0.7 and p = 0.8). Serum levels of IL-6 and TNF-alpha were higher in COVID-19 children than in children with other infectious diseases, but those levels did not correlate with disease severity. Clinical studies in a large pediatric population are necessary to better define the role of the immune-mediated response in SARS-CoV-2 infections in children. MDPI 2021-09-18 /pmc/articles/PMC8473005/ /pubmed/34578450 http://dx.doi.org/10.3390/v13091868 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Curatola, Antonietta Chiaretti, Antonio Ferretti, Serena Bersani, Giulia Lucchetti, Donatella Capossela, Lavinia Sgambato, Alessandro Gatto, Antonio Cytokine Response to SARS-CoV-2 Infection in Children |
title | Cytokine Response to SARS-CoV-2 Infection in Children |
title_full | Cytokine Response to SARS-CoV-2 Infection in Children |
title_fullStr | Cytokine Response to SARS-CoV-2 Infection in Children |
title_full_unstemmed | Cytokine Response to SARS-CoV-2 Infection in Children |
title_short | Cytokine Response to SARS-CoV-2 Infection in Children |
title_sort | cytokine response to sars-cov-2 infection in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473005/ https://www.ncbi.nlm.nih.gov/pubmed/34578450 http://dx.doi.org/10.3390/v13091868 |
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