Cargando…

Stability and Safety of Inhibitor Cystine Knot Peptide, GTx1-15, from the Tarantula Spider Grammostola rosea

Inhibitor cystine knot (ICK) peptides are knotted peptides with three intramolecular disulfide bonds that affect several types of ion channels. Some are proteolytically stable and are promising scaffolds for drug development. GTx1-15 is an ICK peptide that inhibits the voltage-dependent calcium chan...

Descripción completa

Detalles Bibliográficos
Autor principal:	Kimura, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473062/ https://www.ncbi.nlm.nih.gov/pubmed/34564625 http://dx.doi.org/10.3390/toxins13090621

Ejemplares similares

Molecular Cloning and Sequence Analysis of the cDNAs Encoding Toxin-Like Peptides from the Venom Glands of Tarantula Grammostola rosea
por: Kimura, Tadashi, et al.
Publicado: (2012)

High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots
por: Kikuchi, Kyoko, et al.
Publicado: (2015)

Impact of disturbed areas on Theraphosidae spiders diversity (Araneae) and first population data of Grammostola rosea (Walckenaer) in Panul Park
por: Aguilera, Milenko A., et al.
Publicado: (2019)

Killer Knots: Molecular Evolution of Inhibitor Cystine Knot Toxins in Wandering Spiders (Araneae: Ctenidae)
por: Brewer, Michael S., et al.
Publicado: (2023)

The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a
por: Herzig, Volker, et al.
Publicado: (2015)

Identification of a Peptide Toxin from Grammostola spatulata Spider Venom That Blocks Cation-Selective Stretch-Activated Channels
por: Suchyna, Thomas M., et al.
Publicado: (2000)

Cystine Knot Peptides with Tuneable Activity and Mechanism
por: Li, Choi Yi, et al.
Publicado: (2022)

Novel Inhibitor Cystine Knot Peptides from Momordica charantia
por: He, Wen-Jun, et al.
Publicado: (2013)

A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging
por: Jiang, Lei, et al.
Publicado: (2014)

Engineering Agatoxin, a Cystine-Knot Peptide from Spider Venom, as a Molecular Probe for In Vivo Tumor Imaging
por: Moore, Sarah J., et al.
Publicado: (2013)

Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH
por: Tran, Poanna, et al.
Publicado: (2023)

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold
por: Gao, Bin, et al.
Publicado: (2013)

A subfraction obtained from the venom of the tarantula Poecilotheria regalis contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels
por: Díaz-Peña, Luis Fernando, et al.
Publicado: (2023)

Juruin: an antifungal peptide from the venom of the Amazonian Pink Toe spider, Avicularia juruensis, which contains the inhibitory cystine knot motif
por: Ayroza, Gabriela, et al.
Publicado: (2012)

KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007
por: Gracy, Jérôme, et al.
Publicado: (2008)

Proteotranscriptomic Insights into the Venom Composition of the Wolf Spider Lycosa tarantula
por: Koua, Dominique, et al.
Publicado: (2020)

(111)In-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis
por: Jiang, Lei, et al.
Publicado: (2012)

Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking
por: Gao, Xinxin, et al.
Publicado: (2016)

Nanolipoprotein particles for co-delivery of cystine-knot peptides and Fab–based therapeutics
por: Darwish, Martine, et al.
Publicado: (2021)

Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1
por: Glotzbach, Bernhard, et al.
Publicado: (2013)

Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
por: Retzl, Bernhard, et al.
Publicado: (2020)

Species conservation profiles of tarantula spiders (Araneae, Theraphosidae) listed on CITES
por: Fukushima, Caroline, et al.
Publicado: (2019)

Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide
por: Gao, Xinxin, et al.
Publicado: (2021)

Targeting the tumor vasculature with engineered cystine-knot miniproteins
por: Lui, Bonny Gaby, et al.
Publicado: (2020)

Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy
por: Gao, Xinxin, et al.
Publicado: (2019)

(99m)Tc-Labeled Cystine Knot Peptide Targeting Integrin α(v)β(6) for Tumor SPECT Imaging
por: Zhu, Xiaohua, et al.
Publicado: (2014)

Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides
por: Hellinger, Roland, et al.
Publicado: (2021)

Tarantula Books.
Publicado: (1995)

La Tarántula.

Functional Mutation of Multiple Solvent-Exposed Loops in the Ecballium elaterium Trypsin Inhibitor-II Cystine Knot Miniprotein
por: Kimura, Richard H., et al.
Publicado: (2011)

Software para programar radios UHF LCS/LTS 2000/GTX
por: Basañez Álvarez, Keren Happuch
Publicado: (2004)

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design
por: Reinwarth, Michael, et al.
Publicado: (2012)

Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling
por: Hansen, Simon, et al.
Publicado: (2022)

Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots
por: Gracy, Jérôme, et al.
Publicado: (2010)

Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors
por: Kasheverov, Igor E., et al.
Publicado: (2022)

A Chemical Biology Approach to Probing the Folding Pathways of the Inhibitory Cystine Knot (ICK) Peptide ProTx-II
por: McCarthy, Stephen, et al.
Publicado: (2020)

SVM-Based Prediction of Propeptide Cleavage Sites in Spider Toxins Identifies Toxin Innovation in an Australian Tarantula
por: Wong, Emily S. W., et al.
Publicado: (2013)

Tarántulas y escorpiones /
por: Rankin, Wayne
Publicado: (2004)

A Tarantula Bite
por: Baird, J. C.
Publicado: (1889)

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus
por: Lal, Sangeet, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_igc1p9ii43mtmdfu5j93o2tb4s