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A Case of Rubella Caused by Rubella Vaccination

We present an extremely rare case of rubella that developed after rubella vaccine administration. A 54-year-old man complained of back and neck pain for some days. He presented with generalized rash and arthralgia that had persisted for two days before his visit. His vital signs were normal, and art...

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Autores principales: Kamada, Momoka, Kenzaka, Tsuneaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473103/
https://www.ncbi.nlm.nih.gov/pubmed/34579277
http://dx.doi.org/10.3390/vaccines9091040
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author Kamada, Momoka
Kenzaka, Tsuneaki
author_facet Kamada, Momoka
Kenzaka, Tsuneaki
author_sort Kamada, Momoka
collection PubMed
description We present an extremely rare case of rubella that developed after rubella vaccine administration. A 54-year-old man complained of back and neck pain for some days. He presented with generalized rash and arthralgia that had persisted for two days before his visit. His vital signs were normal, and arthralgia had disappeared during an examination, but lymphadenopathy in the left posterior neck and pink papules were observed throughout the body. He had received his first Rubella vaccination 17 days before this visit and had attended a crowded festival. Owing to the rubella epidemic in that prefecture, we performed a rubella antibody test and polymerase chain reaction assay using blood, urine, and pharyngeal swab specimens. Rubella IgG and IgM antibody titers were 3 and 1.48, respectively. The pharyngeal swab yielded positive results for the 1a vaccine strain. Therefore, he was diagnosed with rubella due to rubella vaccination. His symptoms improved eventually. His clinical course was uncomplicated. Symptoms resolved within one week without specific treatment. The vaccine rubella strain is not as highly infectious as wild-type rubella strains. If rubella symptoms appear after vaccination, it must be investigated whether these are vaccine-specific adverse reactions, wild-strain rubella onset, or other eruptive viral infections.
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spelling pubmed-84731032021-09-28 A Case of Rubella Caused by Rubella Vaccination Kamada, Momoka Kenzaka, Tsuneaki Vaccines (Basel) Case Report We present an extremely rare case of rubella that developed after rubella vaccine administration. A 54-year-old man complained of back and neck pain for some days. He presented with generalized rash and arthralgia that had persisted for two days before his visit. His vital signs were normal, and arthralgia had disappeared during an examination, but lymphadenopathy in the left posterior neck and pink papules were observed throughout the body. He had received his first Rubella vaccination 17 days before this visit and had attended a crowded festival. Owing to the rubella epidemic in that prefecture, we performed a rubella antibody test and polymerase chain reaction assay using blood, urine, and pharyngeal swab specimens. Rubella IgG and IgM antibody titers were 3 and 1.48, respectively. The pharyngeal swab yielded positive results for the 1a vaccine strain. Therefore, he was diagnosed with rubella due to rubella vaccination. His symptoms improved eventually. His clinical course was uncomplicated. Symptoms resolved within one week without specific treatment. The vaccine rubella strain is not as highly infectious as wild-type rubella strains. If rubella symptoms appear after vaccination, it must be investigated whether these are vaccine-specific adverse reactions, wild-strain rubella onset, or other eruptive viral infections. MDPI 2021-09-18 /pmc/articles/PMC8473103/ /pubmed/34579277 http://dx.doi.org/10.3390/vaccines9091040 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kamada, Momoka
Kenzaka, Tsuneaki
A Case of Rubella Caused by Rubella Vaccination
title A Case of Rubella Caused by Rubella Vaccination
title_full A Case of Rubella Caused by Rubella Vaccination
title_fullStr A Case of Rubella Caused by Rubella Vaccination
title_full_unstemmed A Case of Rubella Caused by Rubella Vaccination
title_short A Case of Rubella Caused by Rubella Vaccination
title_sort case of rubella caused by rubella vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473103/
https://www.ncbi.nlm.nih.gov/pubmed/34579277
http://dx.doi.org/10.3390/vaccines9091040
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