Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia...

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Autores principales: Guo, Zijing, Zhang, Zhidong, Prajapati, Meera, Li, Yanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473169/
https://www.ncbi.nlm.nih.gov/pubmed/34578457
http://dx.doi.org/10.3390/v13091876
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author Guo, Zijing
Zhang, Zhidong
Prajapati, Meera
Li, Yanmin
author_facet Guo, Zijing
Zhang, Zhidong
Prajapati, Meera
Li, Yanmin
author_sort Guo, Zijing
collection PubMed
description Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.
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spelling pubmed-84731692021-09-28 Lymphopenia Caused by Virus Infections and the Mechanisms Beyond Guo, Zijing Zhang, Zhidong Prajapati, Meera Li, Yanmin Viruses Review Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed. MDPI 2021-09-20 /pmc/articles/PMC8473169/ /pubmed/34578457 http://dx.doi.org/10.3390/v13091876 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guo, Zijing
Zhang, Zhidong
Prajapati, Meera
Li, Yanmin
Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_full Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_fullStr Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_full_unstemmed Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_short Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
title_sort lymphopenia caused by virus infections and the mechanisms beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473169/
https://www.ncbi.nlm.nih.gov/pubmed/34578457
http://dx.doi.org/10.3390/v13091876
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AT prajapatimeera lymphopeniacausedbyvirusinfectionsandthemechanismsbeyond
AT liyanmin lymphopeniacausedbyvirusinfectionsandthemechanismsbeyond

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