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Application of Plant Viruses in Biotechnology, Medicine, and Human Health

Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato virus X (PVX), by virtue of having high aspect rat...

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Detalles Bibliográficos
Autores principales: Venkataraman, Srividhya, Hefferon, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473230/
https://www.ncbi.nlm.nih.gov/pubmed/34578279
http://dx.doi.org/10.3390/v13091697
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author Venkataraman, Srividhya
Hefferon, Kathleen
author_facet Venkataraman, Srividhya
Hefferon, Kathleen
author_sort Venkataraman, Srividhya
collection PubMed
description Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato virus X (PVX), by virtue of having high aspect ratios, make ideal platforms for drug delivery. TMV and PVX both possess rod-shaped structures and single-stranded RNA genomes encapsidated by their respective capsid proteins and have shown great promise as drug delivery systems. Cowpea mosaic virus (CPMV) has an icosahedral structure, and thus brings unique benefits as a nanoparticle. The uses of these three plant viruses as either nanostructures or expression vectors for high value pharmaceutical proteins such as vaccines and antibodies are discussed extensively in the following review. In addition, the potential uses of geminiviruses in medical biotechnology are explored. The uses of these expression vectors in plant biotechnology applications are also discussed. Finally, in this review, we project future prospects for plant viruses in the fields of medicine, human health, prophylaxis, and therapy of human diseases.
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spelling pubmed-84732302021-09-28 Application of Plant Viruses in Biotechnology, Medicine, and Human Health Venkataraman, Srividhya Hefferon, Kathleen Viruses Review Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato virus X (PVX), by virtue of having high aspect ratios, make ideal platforms for drug delivery. TMV and PVX both possess rod-shaped structures and single-stranded RNA genomes encapsidated by their respective capsid proteins and have shown great promise as drug delivery systems. Cowpea mosaic virus (CPMV) has an icosahedral structure, and thus brings unique benefits as a nanoparticle. The uses of these three plant viruses as either nanostructures or expression vectors for high value pharmaceutical proteins such as vaccines and antibodies are discussed extensively in the following review. In addition, the potential uses of geminiviruses in medical biotechnology are explored. The uses of these expression vectors in plant biotechnology applications are also discussed. Finally, in this review, we project future prospects for plant viruses in the fields of medicine, human health, prophylaxis, and therapy of human diseases. MDPI 2021-08-26 /pmc/articles/PMC8473230/ /pubmed/34578279 http://dx.doi.org/10.3390/v13091697 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Venkataraman, Srividhya
Hefferon, Kathleen
Application of Plant Viruses in Biotechnology, Medicine, and Human Health
title Application of Plant Viruses in Biotechnology, Medicine, and Human Health
title_full Application of Plant Viruses in Biotechnology, Medicine, and Human Health
title_fullStr Application of Plant Viruses in Biotechnology, Medicine, and Human Health
title_full_unstemmed Application of Plant Viruses in Biotechnology, Medicine, and Human Health
title_short Application of Plant Viruses in Biotechnology, Medicine, and Human Health
title_sort application of plant viruses in biotechnology, medicine, and human health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473230/
https://www.ncbi.nlm.nih.gov/pubmed/34578279
http://dx.doi.org/10.3390/v13091697
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