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Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study

(1) Background: Chronic kidney disease (CKD) increases the susceptibility to the presence of herpes zoster (HZ). Little is known about the risk factors of HZ in CKD patients; (2) Methods: This is a case-control study. CKD patients diagnosed with HZ between January 2015 and June 2021 in a tertiary ho...

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Autores principales: Li, Zhenxing, Wang, Qiao, Ma, Jiahui, Li, Zhi, Huang, Dong, Huang, Yuzhao, Zhou, Haocheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473266/
https://www.ncbi.nlm.nih.gov/pubmed/34579200
http://dx.doi.org/10.3390/vaccines9090963
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author Li, Zhenxing
Wang, Qiao
Ma, Jiahui
Li, Zhi
Huang, Dong
Huang, Yuzhao
Zhou, Haocheng
author_facet Li, Zhenxing
Wang, Qiao
Ma, Jiahui
Li, Zhi
Huang, Dong
Huang, Yuzhao
Zhou, Haocheng
author_sort Li, Zhenxing
collection PubMed
description (1) Background: Chronic kidney disease (CKD) increases the susceptibility to the presence of herpes zoster (HZ). Little is known about the risk factors of HZ in CKD patients; (2) Methods: This is a case-control study. CKD patients diagnosed with HZ between January 2015 and June 2021 in a tertiary hospital were identified. One age- and gender- matched control was paired for each case, matched to the date of initial HZ diagnosis. Conditional multiple logistic regression was used to evaluate the risk factors associated with the presence of HZ; (3) Results: Forty-seven HZ patients and controls were identified. In general, about 73.40% (69 out of 94) patients were classified at IV to V stages of CKD. Immunosuppressive agents (p = 0.0012) and dialysis therapy (p = 0.021) were reported more frequently in the HZ cohort. Compared with the control group, the total white cell count and lymphocyte count were significantly lower in the HZ group (p value of 0.032 and 0.003, respectively). The conditional logistics regression model revealed that previous immunosuppressants administration (odds ratio: 10.861, 95% CI: 2.092~56.392, p = 0.005) and dialysis therapy (odds ratio: 3.293, 95% CI: 1.047~10.355, p = 0.041) were independent risk factors of HZ in the CKD population; (4) Conclusions: Dialysis and immunosuppressants therapy were associated with greater risk of HZ disease in CKD patients. Further guideline may highlight the necessity of zoster vaccine for patients with CKD, who undertake associated treatment.
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spelling pubmed-84732662021-09-28 Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study Li, Zhenxing Wang, Qiao Ma, Jiahui Li, Zhi Huang, Dong Huang, Yuzhao Zhou, Haocheng Vaccines (Basel) Communication (1) Background: Chronic kidney disease (CKD) increases the susceptibility to the presence of herpes zoster (HZ). Little is known about the risk factors of HZ in CKD patients; (2) Methods: This is a case-control study. CKD patients diagnosed with HZ between January 2015 and June 2021 in a tertiary hospital were identified. One age- and gender- matched control was paired for each case, matched to the date of initial HZ diagnosis. Conditional multiple logistic regression was used to evaluate the risk factors associated with the presence of HZ; (3) Results: Forty-seven HZ patients and controls were identified. In general, about 73.40% (69 out of 94) patients were classified at IV to V stages of CKD. Immunosuppressive agents (p = 0.0012) and dialysis therapy (p = 0.021) were reported more frequently in the HZ cohort. Compared with the control group, the total white cell count and lymphocyte count were significantly lower in the HZ group (p value of 0.032 and 0.003, respectively). The conditional logistics regression model revealed that previous immunosuppressants administration (odds ratio: 10.861, 95% CI: 2.092~56.392, p = 0.005) and dialysis therapy (odds ratio: 3.293, 95% CI: 1.047~10.355, p = 0.041) were independent risk factors of HZ in the CKD population; (4) Conclusions: Dialysis and immunosuppressants therapy were associated with greater risk of HZ disease in CKD patients. Further guideline may highlight the necessity of zoster vaccine for patients with CKD, who undertake associated treatment. MDPI 2021-08-28 /pmc/articles/PMC8473266/ /pubmed/34579200 http://dx.doi.org/10.3390/vaccines9090963 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Li, Zhenxing
Wang, Qiao
Ma, Jiahui
Li, Zhi
Huang, Dong
Huang, Yuzhao
Zhou, Haocheng
Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study
title Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study
title_full Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study
title_fullStr Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study
title_full_unstemmed Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study
title_short Risk Factors for Herpes Zoster in Patients with Chronic Kidney Disease: A Case-Control Study
title_sort risk factors for herpes zoster in patients with chronic kidney disease: a case-control study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473266/
https://www.ncbi.nlm.nih.gov/pubmed/34579200
http://dx.doi.org/10.3390/vaccines9090963
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