Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases

Stereotactic ablative radiotherapy (SABR) planning for adrenal metastases aims to minimize doses to the adjacent kidney. Renal dose constraints for SABR delivery are not well defined. In 20 patients who underwent MR-guided breath-hold SABR in five daily fractions of 8–10 Gy, ipsilateral renal volume...

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Autores principales: van Sörnsen de Koste, John R., van Vliet, Claire C., Schneiders, Famke L., Bruynzeel, Anna M.E., Slotman, Berend J., Palacios, Miguel A., Senan, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473532/
https://www.ncbi.nlm.nih.gov/pubmed/34604552
http://dx.doi.org/10.1016/j.phro.2021.09.001
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author van Sörnsen de Koste, John R.
van Vliet, Claire C.
Schneiders, Famke L.
Bruynzeel, Anna M.E.
Slotman, Berend J.
Palacios, Miguel A.
Senan, Suresh
author_facet van Sörnsen de Koste, John R.
van Vliet, Claire C.
Schneiders, Famke L.
Bruynzeel, Anna M.E.
Slotman, Berend J.
Palacios, Miguel A.
Senan, Suresh
author_sort van Sörnsen de Koste, John R.
collection PubMed
description Stereotactic ablative radiotherapy (SABR) planning for adrenal metastases aims to minimize doses to the adjacent kidney. Renal dose constraints for SABR delivery are not well defined. In 20 patients who underwent MR-guided breath-hold SABR in five daily fractions of 8–10 Gy, ipsilateral renal volumes receiving ≥20 Gy best correlated with loss of renal volumes, with median renal volume reduction being 6% (range: 3%-11%, 10th-90th percentiles). Organ function did not deteriorate in 18 patients, who had post treatment renal function tests available. This suggests that the ipsilateral renal volume receiving 20 Gy can be used as partial organ dose constraint for SABR to targets in the upper abdomen.
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spelling pubmed-84735322021-10-01 Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases van Sörnsen de Koste, John R. van Vliet, Claire C. Schneiders, Famke L. Bruynzeel, Anna M.E. Slotman, Berend J. Palacios, Miguel A. Senan, Suresh Phys Imaging Radiat Oncol Short Communication Stereotactic ablative radiotherapy (SABR) planning for adrenal metastases aims to minimize doses to the adjacent kidney. Renal dose constraints for SABR delivery are not well defined. In 20 patients who underwent MR-guided breath-hold SABR in five daily fractions of 8–10 Gy, ipsilateral renal volumes receiving ≥20 Gy best correlated with loss of renal volumes, with median renal volume reduction being 6% (range: 3%-11%, 10th-90th percentiles). Organ function did not deteriorate in 18 patients, who had post treatment renal function tests available. This suggests that the ipsilateral renal volume receiving 20 Gy can be used as partial organ dose constraint for SABR to targets in the upper abdomen. Elsevier 2021-09-21 /pmc/articles/PMC8473532/ /pubmed/34604552 http://dx.doi.org/10.1016/j.phro.2021.09.001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
van Sörnsen de Koste, John R.
van Vliet, Claire C.
Schneiders, Famke L.
Bruynzeel, Anna M.E.
Slotman, Berend J.
Palacios, Miguel A.
Senan, Suresh
Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
title Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
title_full Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
title_fullStr Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
title_full_unstemmed Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
title_short Renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
title_sort renal atrophy following gated delivery of stereotactic ablative radiotherapy to adrenal metastases
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473532/
https://www.ncbi.nlm.nih.gov/pubmed/34604552
http://dx.doi.org/10.1016/j.phro.2021.09.001
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