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Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
BACKGROUND: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females. AIM: To evaluate secular trends in gastric cancer incidence according to age, sex, and Helicobacter pylori (H. pylori) tre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473596/ https://www.ncbi.nlm.nih.gov/pubmed/34629800 http://dx.doi.org/10.3748/wjg.v27.i34.5764 |
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author | Lin, Yen-Tzeng Chiang, Chun-Ju Yang, Ya-Wen Huang, Shih-Pei You, San-Lin |
author_facet | Lin, Yen-Tzeng Chiang, Chun-Ju Yang, Ya-Wen Huang, Shih-Pei You, San-Lin |
author_sort | Lin, Yen-Tzeng |
collection | PubMed |
description | BACKGROUND: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females. AIM: To evaluate secular trends in gastric cancer incidence according to age, sex, and Helicobacter pylori (H. pylori) treatment in Taiwan. METHODS: In this population-based study, we used the national Taiwan Cancer Registry database. Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan. Pearson’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for H. pylori infection. RESULTS: The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females. However, the decreasing trends differed by sex, with an annual percent change of -2.58% in males and -2.14% in females. The age-specific incidence rates increased with age. Within the same age group, more recent time periods showed lower incidence rates than greater time periods. Similarly, the sex ratio was lower in later birth cohorts than in earlier birth cohorts. Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for H. pylori infection during 2005 to 2016 (r = 0.72). CONCLUSION: We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan. These results support H. pylori eradication programs in Taiwan. |
format | Online Article Text |
id | pubmed-8473596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-84735962021-10-08 Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study Lin, Yen-Tzeng Chiang, Chun-Ju Yang, Ya-Wen Huang, Shih-Pei You, San-Lin World J Gastroenterol Observational Study BACKGROUND: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females. AIM: To evaluate secular trends in gastric cancer incidence according to age, sex, and Helicobacter pylori (H. pylori) treatment in Taiwan. METHODS: In this population-based study, we used the national Taiwan Cancer Registry database. Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan. Pearson’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for H. pylori infection. RESULTS: The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females. However, the decreasing trends differed by sex, with an annual percent change of -2.58% in males and -2.14% in females. The age-specific incidence rates increased with age. Within the same age group, more recent time periods showed lower incidence rates than greater time periods. Similarly, the sex ratio was lower in later birth cohorts than in earlier birth cohorts. Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for H. pylori infection during 2005 to 2016 (r = 0.72). CONCLUSION: We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan. These results support H. pylori eradication programs in Taiwan. Baishideng Publishing Group Inc 2021-09-14 2021-09-14 /pmc/articles/PMC8473596/ /pubmed/34629800 http://dx.doi.org/10.3748/wjg.v27.i34.5764 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Observational Study Lin, Yen-Tzeng Chiang, Chun-Ju Yang, Ya-Wen Huang, Shih-Pei You, San-Lin Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study |
title | Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study |
title_full | Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study |
title_fullStr | Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study |
title_full_unstemmed | Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study |
title_short | Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study |
title_sort | secular decreasing trends in gastric cancer incidence in taiwan: a population-based cancer registry study |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473596/ https://www.ncbi.nlm.nih.gov/pubmed/34629800 http://dx.doi.org/10.3748/wjg.v27.i34.5764 |
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