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Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study

BACKGROUND: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females. AIM: To evaluate secular trends in gastric cancer incidence according to age, sex, and Helicobacter pylori (H. pylori) tre...

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Autores principales: Lin, Yen-Tzeng, Chiang, Chun-Ju, Yang, Ya-Wen, Huang, Shih-Pei, You, San-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473596/
https://www.ncbi.nlm.nih.gov/pubmed/34629800
http://dx.doi.org/10.3748/wjg.v27.i34.5764
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author Lin, Yen-Tzeng
Chiang, Chun-Ju
Yang, Ya-Wen
Huang, Shih-Pei
You, San-Lin
author_facet Lin, Yen-Tzeng
Chiang, Chun-Ju
Yang, Ya-Wen
Huang, Shih-Pei
You, San-Lin
author_sort Lin, Yen-Tzeng
collection PubMed
description BACKGROUND: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females. AIM: To evaluate secular trends in gastric cancer incidence according to age, sex, and Helicobacter pylori (H. pylori) treatment in Taiwan. METHODS: In this population-based study, we used the national Taiwan Cancer Registry database. Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan. Pearson’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for H. pylori infection. RESULTS: The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females. However, the decreasing trends differed by sex, with an annual percent change of -2.58% in males and -2.14% in females. The age-specific incidence rates increased with age. Within the same age group, more recent time periods showed lower incidence rates than greater time periods. Similarly, the sex ratio was lower in later birth cohorts than in earlier birth cohorts. Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for H. pylori infection during 2005 to 2016 (r = 0.72). CONCLUSION: We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan. These results support H. pylori eradication programs in Taiwan.
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spelling pubmed-84735962021-10-08 Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study Lin, Yen-Tzeng Chiang, Chun-Ju Yang, Ya-Wen Huang, Shih-Pei You, San-Lin World J Gastroenterol Observational Study BACKGROUND: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females. AIM: To evaluate secular trends in gastric cancer incidence according to age, sex, and Helicobacter pylori (H. pylori) treatment in Taiwan. METHODS: In this population-based study, we used the national Taiwan Cancer Registry database. Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan. Pearson’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for H. pylori infection. RESULTS: The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females. However, the decreasing trends differed by sex, with an annual percent change of -2.58% in males and -2.14% in females. The age-specific incidence rates increased with age. Within the same age group, more recent time periods showed lower incidence rates than greater time periods. Similarly, the sex ratio was lower in later birth cohorts than in earlier birth cohorts. Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for H. pylori infection during 2005 to 2016 (r = 0.72). CONCLUSION: We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan. These results support H. pylori eradication programs in Taiwan. Baishideng Publishing Group Inc 2021-09-14 2021-09-14 /pmc/articles/PMC8473596/ /pubmed/34629800 http://dx.doi.org/10.3748/wjg.v27.i34.5764 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Lin, Yen-Tzeng
Chiang, Chun-Ju
Yang, Ya-Wen
Huang, Shih-Pei
You, San-Lin
Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
title Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
title_full Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
title_fullStr Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
title_full_unstemmed Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
title_short Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
title_sort secular decreasing trends in gastric cancer incidence in taiwan: a population-based cancer registry study
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473596/
https://www.ncbi.nlm.nih.gov/pubmed/34629800
http://dx.doi.org/10.3748/wjg.v27.i34.5764
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