Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis

BACKGROUND: Platinum‐based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows finite therapeutic efficacy in patients suffering from brain metastasis (BM). The intrinsic changes of BM cells, which contribute to the poor results remain unknown. METHODS:...

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Detalles Bibliográficos
Autores principales: Liu, Wenwen, Zhou, Yang, Duan, Wenzhe, Song, Jing, Wei, Song, Xia, Shengkai, Wang, Yingyan, Du, Xiaohui, Li, Encheng, Ren, Caixia, Wang, Wei, Zhan, Qimin, Wang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473645/
https://www.ncbi.nlm.nih.gov/pubmed/34586745
http://dx.doi.org/10.1002/ctm2.517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473645/
https://www.ncbi.nlm.nih.gov/pubmed/34586745
http://dx.doi.org/10.1002/ctm2.517

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