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Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies
Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473769/ https://www.ncbi.nlm.nih.gov/pubmed/34560530 http://dx.doi.org/10.1016/j.nicl.2021.102830 |
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author | Zacková, Mgr. Lenka Jáni, Mgr. Martin Brázdil, Milan Nikolova, Yuliya S. Marečková, Klára |
author_facet | Zacková, Mgr. Lenka Jáni, Mgr. Martin Brázdil, Milan Nikolova, Yuliya S. Marečková, Klára |
author_sort | Zacková, Mgr. Lenka |
collection | PubMed |
description | Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. 48 voxel-based morphometry (VBM) studies of individuals with MDD, MCI, and age-matched controls and demonstrated that MDD and MCI patients had shared volumetric reductions in a number of regions including the insula, superior temporal gyrus (STG), inferior frontal gyrus, amygdala, hippocampus, and thalamus. We suggest that the shared volumetric reductions in the insula and STG might reflect communication deficits and infrequent participation in mentally or socially stimulating activities, which have been described as risk factors for both MCI and MDD. We also suggest that the disease-specific structural changes might reflect the disease-specific symptoms such as poor integration of emotional information, feelings of helplessness and worthlessness, and anhedonia in MDD. These findings could contribute to better understanding of the origins of MDD-MCI comorbidity and facilitate development of early interventions. |
format | Online Article Text |
id | pubmed-8473769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84737692021-10-01 Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies Zacková, Mgr. Lenka Jáni, Mgr. Martin Brázdil, Milan Nikolova, Yuliya S. Marečková, Klára Neuroimage Clin Review Article Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. 48 voxel-based morphometry (VBM) studies of individuals with MDD, MCI, and age-matched controls and demonstrated that MDD and MCI patients had shared volumetric reductions in a number of regions including the insula, superior temporal gyrus (STG), inferior frontal gyrus, amygdala, hippocampus, and thalamus. We suggest that the shared volumetric reductions in the insula and STG might reflect communication deficits and infrequent participation in mentally or socially stimulating activities, which have been described as risk factors for both MCI and MDD. We also suggest that the disease-specific structural changes might reflect the disease-specific symptoms such as poor integration of emotional information, feelings of helplessness and worthlessness, and anhedonia in MDD. These findings could contribute to better understanding of the origins of MDD-MCI comorbidity and facilitate development of early interventions. Elsevier 2021-09-16 /pmc/articles/PMC8473769/ /pubmed/34560530 http://dx.doi.org/10.1016/j.nicl.2021.102830 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Zacková, Mgr. Lenka Jáni, Mgr. Martin Brázdil, Milan Nikolova, Yuliya S. Marečková, Klára Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies |
title | Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies |
title_full | Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies |
title_fullStr | Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies |
title_full_unstemmed | Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies |
title_short | Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies |
title_sort | cognitive impairment and depression: meta-analysis of structural magnetic resonance imaging studies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473769/ https://www.ncbi.nlm.nih.gov/pubmed/34560530 http://dx.doi.org/10.1016/j.nicl.2021.102830 |
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