Cargando…

Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond

Wnt signaling plays crucial roles in development and tissue homeostasis, and its dysregulation leads to various diseases, notably cancer. Wnt/β-catenin signaling is initiated when the glycoprotein Wnt binds to and forms a ternary complex with the Frizzled and low-density lipoprotein receptor-related...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Wonyoung, Jho, Eek-hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473786/ https://www.ncbi.nlm.nih.gov/pubmed/34589484 http://dx.doi.org/10.3389/fcell.2021.714330

Ejemplares similares

Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling
por: Haack, Fiete, et al.
Publicado: (2021)

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
por: Ren, Qian, et al.
Publicado: (2021)

β-Arrestin Promotes Wnt-induced Low Density Lipoprotein Receptor-related Protein 6 (Lrp6) Phosphorylation via Increased Membrane Recruitment of Amer1 Protein
por: Kříž, Vítězslav, et al.
Publicado: (2014)

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function
por: Geng, Shuang, et al.
Publicado: (2023)

Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
por: de Winter, Twan J. J., et al.
Publicado: (2021)

WNT/β-Catenin Signaling in Vertebrate Eye Development
por: Fujimura, Naoko
Publicado: (2016)

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Is a Negative Regulator of Oligodendrocyte Progenitor Cell Differentiation in the Adult Mouse Brain
por: Auderset, Loic, et al.
Publicado: (2020)

Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice
por: Jin, Yong-Ri, et al.
Publicado: (2020)

Merlin, a regulator of Hippo signaling, regulates Wnt/β-catenin signaling
por: Kim, Soyoung, et al.
Publicado: (2016)

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6
por: Perrody, Elsa, et al.
Publicado: (2016)

The Role of Wnt/β-Catenin Pathway Mediators in Aortic Valve Stenosis
por: Khan, Kashif, et al.
Publicado: (2020)

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
por: Bernatik, Ondrej, et al.
Publicado: (2021)

Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review
por: Kim, Minseong, et al.
Publicado: (2014)

Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
por: Sutton, Gemma, et al.
Publicado: (2021)

Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
por: Song, Yonghee, et al.
Publicado: (2018)

ENO3 Inhibits Growth and Metastasis of Hepatocellular Carcinoma via Wnt/β-Catenin Signaling Pathway
por: Cui, Honglei, et al.
Publicado: (2021)

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates
por: Mattes, Benjamin, et al.
Publicado: (2018)

Mettl14 Attenuates Cardiac Ischemia/Reperfusion Injury by Regulating Wnt1/β-Catenin Signaling Pathway
por: Pang, Ping, et al.
Publicado: (2021)

Impact of Sepsis on High-Density Lipoprotein Metabolism
por: Reisinger, Alexander C., et al.
Publicado: (2022)

Long Noncoding RNA lnc-TSSK2-8 Activates Canonical Wnt/β-Catenin Signaling Through Small Heat Shock Proteins HSPA6 and CRYAB
por: Fa, Jingjing, et al.
Publicado: (2021)

ELK3 Mediated by ZEB1 Facilitates the Growth and Metastasis of Pancreatic Carcinoma by Activating the Wnt/β-Catenin Pathway
por: Zhao, Qiuyan, et al.
Publicado: (2021)

WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells
por: Li, Tianqi, et al.
Publicado: (2022)

TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease
por: Lee, Eun Ji, et al.
Publicado: (2020)

Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering
por: Wang, Xueqi, et al.
Publicado: (2022)

Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells
por: Singh, Vikash, et al.
Publicado: (2023)

Hyperactivation of Wnt/β-catenin and Jak/Stat3 pathways in human and zebrafish foetal growth restriction models: Implications for pharmacological rescue
por: Risato, Giovanni, et al.
Publicado: (2022)

Curcumin-primed periodontal ligament stem cells-derived extracellular vesicles improve osteogenic ability through the Wnt/β-catenin pathway
por: Lan, Qian, et al.
Publicado: (2023)

Overexpression of long noncoding RNA 4933425B07Rik leads to renal hypoplasia by inactivating Wnt/β-catenin signaling pathway
por: Xue, Shanshan, et al.
Publicado: (2023)

Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites
por: Islam, Mohammad Majharul, et al.
Publicado: (2022)

Artemisia argyi Essential Oil Inhibits Hepatocellular Carcinoma Metastasis via Suppression of DEPDC1 Dependent Wnt/β-Catenin Signaling Pathway
por: Li, Yanli, et al.
Publicado: (2021)

Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer
por: Kozmikova, Iryna, et al.
Publicado: (2020)

Editorial: Beyond Cardiovascular Disease: Challenging New Pathways in Lipid and Lipoprotein Metabolism
por: Passarelli, Marisa, et al.
Publicado: (2022)

ITGB1-DT Facilitates Lung Adenocarcinoma Progression via Forming a Positive Feedback Loop With ITGB1/Wnt/β-Catenin/MYC
por: Chang, Ruimin, et al.
Publicado: (2021)

Circadian Rhythm Gene PER3 Negatively Regulates Stemness of Prostate Cancer Stem Cells via WNT/β-Catenin Signaling in Tumor Microenvironment
por: Li, Qilin, et al.
Publicado: (2021)

USP36-Mediated Deubiquitination of DOCK4 Contributes to the Diabetic Renal Tubular Epithelial Cell Injury via Wnt/β-Catenin Signaling Pathway
por: Zhu, Suwei, et al.
Publicado: (2021)

New Insights into Wnt–Lrp5/6–β-Catenin Signaling in Mechanotransduction
por: Kang, Kyung Shin, et al.
Publicado: (2015)

Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling
por: Hwang, Woong Y, et al.
Publicado: (2022)

Knockdown of Circular RNA hsa_circ_PVT1 Inhibited Laryngeal Cancer Progression via Preventing wnt4/β-Catenin Signaling Pathway Activation
por: Yu, Feng, et al.
Publicado: (2021)

Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development
por: Aman, Andrew J, et al.
Publicado: (2018)

TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex
por: Zimmerli, Dario, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pd4kop457juqmj7t436iqjs0hq