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Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM

Electrospinning is a promising method to fabricate bioengineered scaffolds, thanks to utilizing various types of biopolymers, flexible structures, and also the diversity of output properties. Mechanical properties are one of the major components of scaffold design to fabricate an efficacious artific...

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Autores principales: Barazesh, Alireza, Navidbakhsh, Mahdi, Abouei Mehrizi, Ali, Koosha, Mojtaba, Razavi Bazaz, Sajad, Li, Tianduo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473815/
https://www.ncbi.nlm.nih.gov/pubmed/34589472
http://dx.doi.org/10.3389/fbioe.2021.718718
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author Barazesh, Alireza
Navidbakhsh, Mahdi
Abouei Mehrizi, Ali
Koosha, Mojtaba
Razavi Bazaz, Sajad
Li, Tianduo
author_facet Barazesh, Alireza
Navidbakhsh, Mahdi
Abouei Mehrizi, Ali
Koosha, Mojtaba
Razavi Bazaz, Sajad
Li, Tianduo
author_sort Barazesh, Alireza
collection PubMed
description Electrospinning is a promising method to fabricate bioengineered scaffolds, thanks to utilizing various types of biopolymers, flexible structures, and also the diversity of output properties. Mechanical properties are one of the major components of scaffold design to fabricate an efficacious artificial substitute for the natural extracellular matrix. Additionally, fiber orientations, as one of the scaffold structural parameters, could play a crucial role in the application of fabricated fibrous scaffolds. In this study, gelatin was used as a highly biocompatible polymer in blend with cellulose acetate (CA), a polysaccharide, to enhance the achievable range of mechanical characteristics to fabricated fibrous electrospun scaffolds. By altering input variables, such as polymers concentration, weight ratio, and mandrel rotation speed, scaffolds with various mechanical and morphological properties could be achieved. As expected, the electrospun scaffold with a higher mandrel rotation speed shows higher fiber alignment. A wide range of mechanical properties were gained through different values of polymer ratio and total concentration. A general improvement in mechanical strength was observed by increasing the concentration and CA content in the solution, but contradictory effects, such as high viscosity in more concentrated solutions, influenced the mechanical characteristics as well. A response surface method was applied on experimental results in order to describe a continuous variation of Young’s modulus, yield stress, and strain at rupture. A full quadratic version of equations with the 95% confidence level was applied for the response modeling. This model would be an aid for engineers to adjust mandrel rotation speed, solution concentration, and gelatin/CA ratio to achieve desired mechanical and structural properties.
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spelling pubmed-84738152021-09-28 Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM Barazesh, Alireza Navidbakhsh, Mahdi Abouei Mehrizi, Ali Koosha, Mojtaba Razavi Bazaz, Sajad Li, Tianduo Front Bioeng Biotechnol Bioengineering and Biotechnology Electrospinning is a promising method to fabricate bioengineered scaffolds, thanks to utilizing various types of biopolymers, flexible structures, and also the diversity of output properties. Mechanical properties are one of the major components of scaffold design to fabricate an efficacious artificial substitute for the natural extracellular matrix. Additionally, fiber orientations, as one of the scaffold structural parameters, could play a crucial role in the application of fabricated fibrous scaffolds. In this study, gelatin was used as a highly biocompatible polymer in blend with cellulose acetate (CA), a polysaccharide, to enhance the achievable range of mechanical characteristics to fabricated fibrous electrospun scaffolds. By altering input variables, such as polymers concentration, weight ratio, and mandrel rotation speed, scaffolds with various mechanical and morphological properties could be achieved. As expected, the electrospun scaffold with a higher mandrel rotation speed shows higher fiber alignment. A wide range of mechanical properties were gained through different values of polymer ratio and total concentration. A general improvement in mechanical strength was observed by increasing the concentration and CA content in the solution, but contradictory effects, such as high viscosity in more concentrated solutions, influenced the mechanical characteristics as well. A response surface method was applied on experimental results in order to describe a continuous variation of Young’s modulus, yield stress, and strain at rupture. A full quadratic version of equations with the 95% confidence level was applied for the response modeling. This model would be an aid for engineers to adjust mandrel rotation speed, solution concentration, and gelatin/CA ratio to achieve desired mechanical and structural properties. Frontiers Media S.A. 2021-09-13 /pmc/articles/PMC8473815/ /pubmed/34589472 http://dx.doi.org/10.3389/fbioe.2021.718718 Text en Copyright © 2021 Barazesh, Navidbakhsh, Abouei Mehrizi, Koosha, Razavi Bazaz and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Barazesh, Alireza
Navidbakhsh, Mahdi
Abouei Mehrizi, Ali
Koosha, Mojtaba
Razavi Bazaz, Sajad
Li, Tianduo
Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM
title Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM
title_full Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM
title_fullStr Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM
title_full_unstemmed Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM
title_short Simultaneous Modeling of Young’s Modulus, Yield Stress, and Rupture Strain of Gelatin/Cellulose Acetate Microfibrous/Nanofibrous Scaffolds Using RSM
title_sort simultaneous modeling of young’s modulus, yield stress, and rupture strain of gelatin/cellulose acetate microfibrous/nanofibrous scaffolds using rsm
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473815/
https://www.ncbi.nlm.nih.gov/pubmed/34589472
http://dx.doi.org/10.3389/fbioe.2021.718718
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