Cargando…

Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1

Ginsenoside Rg3 is a steroidal saponin isolated from Panax ginseng. Previous studies have shown that Rg3 treatment downregulates the activity of rapamycin complex 1 (mTORC1) activity and inhibits the growth of cancer cells. However, the inhibitory effect of Rg3 on cancer cells is associated with hig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wei, Zhang, Sheng-Xiong, Ai, Bo, Pan, Hua-Feng, Zhang, Dan, Jiang, Yu, Hu, Lei-Hao, Sun, Ling-Ling, Chen, Zhe-Sheng, Lin, Li-Zhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473834/ https://www.ncbi.nlm.nih.gov/pubmed/34589493 http://dx.doi.org/10.3389/fcell.2021.730309

Ejemplares similares

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma
por: Li, Ting, et al.
Publicado: (2020)

mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
por: Peng, Qinqin, et al.
Publicado: (2021)

The crosstalk between MYC and mTORC1 during osteoclastogenesis
por: Bae, Seyeon, et al.
Publicado: (2022)

Role of ARHGEF3 as a GEF and mTORC2 Regulator
por: Khaliq, Sana Abdul, et al.
Publicado: (2022)

Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling
por: Li, Ningning, et al.
Publicado: (2023)

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back
por: Rehbein, Ulrike, et al.
Publicado: (2021)

Autophagy regulated by the HIF/REDD1/mTORC1 signaling is progressively increased during erythroid differentiation under hypoxia
por: Li, Jian, et al.
Publicado: (2022)

Dual Inhibition of mTORC1/2 Reduces Migration of Cholangiocarcinoma Cells by Regulation of Matrixmetalloproteinases
por: Joechle, Katharina, et al.
Publicado: (2022)

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila
por: Liu, Peiduo, et al.
Publicado: (2022)

A critical role for mTORC1 in erythropoiesis and anemia
por: Knight, Zachary A, et al.
Publicado: (2014)

Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis
por: Sparta, Breanne, et al.
Publicado: (2023)

mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells
por: Rosario, Fredrick J., et al.
Publicado: (2020)

The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis
por: Liu, Weiwei, et al.
Publicado: (2021)

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling
por: Liu, Ji-Ting, et al.
Publicado: (2021)

Possible Involvement of the Nutrient and Energy Sensors mTORC1 and AMPK in Cell Fate Diversification in a Non-Metazoan Organism
por: Gross, Julian D., et al.
Publicado: (2021)

mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts
por: Wu, Su, et al.
Publicado: (2019)

Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities
por: De Meulemeester, Ann-Sofie, et al.
Publicado: (2022)

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
por: Carroll, Bernadette, et al.
Publicado: (2016)

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
por: Covarrubias, Anthony J, et al.
Publicado: (2016)

Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
por: Carroll, Bernadette, et al.
Publicado: (2020)

Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
por: Figlia, Gianluca, et al.
Publicado: (2017)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia
por: Lim, Soyeon, et al.
Publicado: (2021)

Transcriptional regulation of mTORC1 in cancer
por: Di Malta, Chiara, et al.
Publicado: (2018)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
por: Conde-Dusman, María J, et al.
Publicado: (2021)

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop
por: Liu, Xu, et al.
Publicado: (2021)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

BUB1B promotes hepatocellular carcinoma progression via activation of the mTORC1 signaling pathway
por: Qiu, Jiannan, et al.
Publicado: (2020)

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
por: Jewell, Jenna L, et al.
Publicado: (2019)

RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1
por: Wang, Tao, et al.
Publicado: (2019)

Ginsenosides on stem cells fate specification—a novel perspective
por: Liu, Ying, et al.
Publicado: (2023)

SNAT7 regulates mTORC1 via macropinocytosis
por: Meng, Delong, et al.
Publicado: (2022)

Comparative Pharmacokinetics of Ginsenoside Rg(3) and Ginsenoside Rh(2) after Oral Administration of Ginsenoside Rg(3) in Normal and Walker 256 Tumor-bearing Rats
por: Fan, He, et al.
Publicado: (2016)

mTORC2 dictates Warburg effect and drug resistance
por: Masui, Kenta, et al.
Publicado: (2014)

Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo
por: Pan, Xiao-dong, et al.
Publicado: (2017)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Architecture of the human mTORC2 core complex
por: Stuttfeld, Edward, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1f9l21ils6gjbo60i7njc2ger0