Role of Exosomes in Brain Diseases

Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the main...

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Detalles Bibliográficos
Autores principales: Zhang, Nan, He, Fengling, Li, Ting, Chen, Jinzhi, Jiang, Liping, Ouyang, Xin-Ping, Zuo, Lielian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473913/
https://www.ncbi.nlm.nih.gov/pubmed/34588957
http://dx.doi.org/10.3389/fncel.2021.743353
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author Zhang, Nan
He, Fengling
Li, Ting
Chen, Jinzhi
Jiang, Liping
Ouyang, Xin-Ping
Zuo, Lielian
author_facet Zhang, Nan
He, Fengling
Li, Ting
Chen, Jinzhi
Jiang, Liping
Ouyang, Xin-Ping
Zuo, Lielian
author_sort Zhang, Nan
collection PubMed
description Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.
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spelling pubmed-84739132021-09-28 Role of Exosomes in Brain Diseases Zhang, Nan He, Fengling Li, Ting Chen, Jinzhi Jiang, Liping Ouyang, Xin-Ping Zuo, Lielian Front Cell Neurosci Cellular Neuroscience Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases. Frontiers Media S.A. 2021-09-13 /pmc/articles/PMC8473913/ /pubmed/34588957 http://dx.doi.org/10.3389/fncel.2021.743353 Text en Copyright © 2021 Zhang, He, Li, Chen, Jiang, Ouyang and Zuo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Zhang, Nan
He, Fengling
Li, Ting
Chen, Jinzhi
Jiang, Liping
Ouyang, Xin-Ping
Zuo, Lielian
Role of Exosomes in Brain Diseases
title Role of Exosomes in Brain Diseases
title_full Role of Exosomes in Brain Diseases
title_fullStr Role of Exosomes in Brain Diseases
title_full_unstemmed Role of Exosomes in Brain Diseases
title_short Role of Exosomes in Brain Diseases
title_sort role of exosomes in brain diseases
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473913/
https://www.ncbi.nlm.nih.gov/pubmed/34588957
http://dx.doi.org/10.3389/fncel.2021.743353
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AT jiangliping roleofexosomesinbraindiseases
AT ouyangxinping roleofexosomesinbraindiseases
AT zuolielian roleofexosomesinbraindiseases

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