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Met is required for oligodendrocyte progenitor cell migration in Danio rerio
During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC mig...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473979/ https://www.ncbi.nlm.nih.gov/pubmed/34568921 http://dx.doi.org/10.1093/g3journal/jkab265 |
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author | Ali, Maria F Latimer, Andrew J Wang, Yinxue Hogenmiller, Leah Fontenas, Laura Isabella, Adam J Moens, Cecilia B Yu, Guoqiang Kucenas, Sarah |
author_facet | Ali, Maria F Latimer, Andrew J Wang, Yinxue Hogenmiller, Leah Fontenas, Laura Isabella, Adam J Moens, Cecilia B Yu, Guoqiang Kucenas, Sarah |
author_sort | Ali, Maria F |
collection | PubMed |
description | During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo, the role of Met signaling in OPC migration and provide new insight into how OPC migration is regulated during development. |
format | Online Article Text |
id | pubmed-8473979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84739792021-09-27 Met is required for oligodendrocyte progenitor cell migration in Danio rerio Ali, Maria F Latimer, Andrew J Wang, Yinxue Hogenmiller, Leah Fontenas, Laura Isabella, Adam J Moens, Cecilia B Yu, Guoqiang Kucenas, Sarah G3 (Bethesda) Investigation During vertebrate central nervous system development, most oligodendrocyte progenitor cells (OPCs) are specified in the ventral spinal cord and must migrate throughout the neural tube until they become evenly distributed, occupying non-overlapping domains. While this process of developmental OPC migration is well characterized, the nature of the molecular mediators that govern it remain largely unknown. Here, using zebrafish as a model, we demonstrate that Met signaling is required for initial developmental migration of OPCs, and, using cell-specific knock-down of Met signaling, show that Met acts cell-autonomously in OPCs. Taken together, these findings demonstrate in vivo, the role of Met signaling in OPC migration and provide new insight into how OPC migration is regulated during development. Oxford University Press 2021-07-27 /pmc/articles/PMC8473979/ /pubmed/34568921 http://dx.doi.org/10.1093/g3journal/jkab265 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Investigation Ali, Maria F Latimer, Andrew J Wang, Yinxue Hogenmiller, Leah Fontenas, Laura Isabella, Adam J Moens, Cecilia B Yu, Guoqiang Kucenas, Sarah Met is required for oligodendrocyte progenitor cell migration in Danio rerio |
title | Met is required for oligodendrocyte progenitor cell migration in Danio rerio |
title_full | Met is required for oligodendrocyte progenitor cell migration in Danio rerio |
title_fullStr | Met is required for oligodendrocyte progenitor cell migration in Danio rerio |
title_full_unstemmed | Met is required for oligodendrocyte progenitor cell migration in Danio rerio |
title_short | Met is required for oligodendrocyte progenitor cell migration in Danio rerio |
title_sort | met is required for oligodendrocyte progenitor cell migration in danio rerio |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473979/ https://www.ncbi.nlm.nih.gov/pubmed/34568921 http://dx.doi.org/10.1093/g3journal/jkab265 |
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