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Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome

Introduction: Central obesity appears to play a major role in the pathogenesis of metabolic disorders in polycystic ovary syndrome. Insulin resistance and carbohydrate disorders are associated with dysfunctional secretion of various adipokines by the adipose tissue. Objectives: This study aimed to e...

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Autores principales: Kolan′ska-Dams, Ewelina, Boinska, Joanna, Socha, Maciej W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: HBKU Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474077/
https://www.ncbi.nlm.nih.gov/pubmed/34604014
http://dx.doi.org/10.5339/qmj.2021.34
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author Kolan′ska-Dams, Ewelina
Boinska, Joanna
Socha, Maciej W.
author_facet Kolan′ska-Dams, Ewelina
Boinska, Joanna
Socha, Maciej W.
author_sort Kolan′ska-Dams, Ewelina
collection PubMed
description Introduction: Central obesity appears to play a major role in the pathogenesis of metabolic disorders in polycystic ovary syndrome. Insulin resistance and carbohydrate disorders are associated with dysfunctional secretion of various adipokines by the adipose tissue. Objectives: This study aimed to evaluate leptin, apelin, and visfatin against a background of carbohydrate metabolism parameters in patients diagnosed de novo with polycystic ovary syndrome (PCOS). Material and methods: The study group consisted of 40 patients with PCOS (mean age, 29 years) diagnosed in accordance with the American Society for Reproductive Medicine criteria from 2003. The control group consisted of 37 clinically healthy women (mean age, 26 years). All controls had regular menses and no clinical or biochemical signs of hyperandrogenism. Concentrations of leptin, apelin, visfatin, and insulin were measured by immunoenzymatic methods. Glucose concentrations were determined using spectrophotometry. Results: Significantly higher concentrations of leptin, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) index, and the immunoreactive insulin (IRI)/glucose index were found in the PCOS group than in the control group. Notably, the concentration of apelin was over five times lower in the PCOS group than in the control group. In patients with PCOS, a positive correlation was found between the concentrations of insulin and leptin and concentrations of leptin and IRI/glucose. Patients of the PCOS group with body mass index (BMI) ≥  25 had significantly higher values of leptin, insulin, HOMA-IR index, and IRI/glucose index than patients of the PCOS group with normal BMI. In the PCOS group, a positive correlation was found between BMI and leptin concentration (r = 0.7176; p < 0.0001) and carbohydrate metabolism, such as insulin (r = 0.5524; p = 0.0003), glucose (r = 0.3843; p = 0.0157), HOMA-IR (r = 0.5895; p < 0.0001), and IRI/glucose (r = 0.3872; p = 0.0163). These findings were not observed in the control group. Conclusions: (1) Increased leptin concentration observed in women diagnosed de novo with PCOS as well as positive correlations between leptin and HOMA-IR, and IRI/glucose and BMI may indicate a potential role of leptin in the reduction of tissue sensitivity to insulin. (2) Significantly lower apelin concentration in the PCOS group (>5 fold) than in the control group, associated with a concomitant increase in leptin, may also contribute to carbohydrate metabolism disorders occurring in the course of PCOS.
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spelling pubmed-84740772021-10-01 Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome Kolan′ska-Dams, Ewelina Boinska, Joanna Socha, Maciej W. Qatar Med J Research Article Introduction: Central obesity appears to play a major role in the pathogenesis of metabolic disorders in polycystic ovary syndrome. Insulin resistance and carbohydrate disorders are associated with dysfunctional secretion of various adipokines by the adipose tissue. Objectives: This study aimed to evaluate leptin, apelin, and visfatin against a background of carbohydrate metabolism parameters in patients diagnosed de novo with polycystic ovary syndrome (PCOS). Material and methods: The study group consisted of 40 patients with PCOS (mean age, 29 years) diagnosed in accordance with the American Society for Reproductive Medicine criteria from 2003. The control group consisted of 37 clinically healthy women (mean age, 26 years). All controls had regular menses and no clinical or biochemical signs of hyperandrogenism. Concentrations of leptin, apelin, visfatin, and insulin were measured by immunoenzymatic methods. Glucose concentrations were determined using spectrophotometry. Results: Significantly higher concentrations of leptin, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) index, and the immunoreactive insulin (IRI)/glucose index were found in the PCOS group than in the control group. Notably, the concentration of apelin was over five times lower in the PCOS group than in the control group. In patients with PCOS, a positive correlation was found between the concentrations of insulin and leptin and concentrations of leptin and IRI/glucose. Patients of the PCOS group with body mass index (BMI) ≥  25 had significantly higher values of leptin, insulin, HOMA-IR index, and IRI/glucose index than patients of the PCOS group with normal BMI. In the PCOS group, a positive correlation was found between BMI and leptin concentration (r = 0.7176; p < 0.0001) and carbohydrate metabolism, such as insulin (r = 0.5524; p = 0.0003), glucose (r = 0.3843; p = 0.0157), HOMA-IR (r = 0.5895; p < 0.0001), and IRI/glucose (r = 0.3872; p = 0.0163). These findings were not observed in the control group. Conclusions: (1) Increased leptin concentration observed in women diagnosed de novo with PCOS as well as positive correlations between leptin and HOMA-IR, and IRI/glucose and BMI may indicate a potential role of leptin in the reduction of tissue sensitivity to insulin. (2) Significantly lower apelin concentration in the PCOS group (>5 fold) than in the control group, associated with a concomitant increase in leptin, may also contribute to carbohydrate metabolism disorders occurring in the course of PCOS. HBKU Press 2021-08-31 /pmc/articles/PMC8474077/ /pubmed/34604014 http://dx.doi.org/10.5339/qmj.2021.34 Text en © 2021 Kolan′ska-Dams, Boinska, Socha, licensee HBKU Press. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kolan′ska-Dams, Ewelina
Boinska, Joanna
Socha, Maciej W.
Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
title Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
title_full Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
title_fullStr Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
title_full_unstemmed Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
title_short Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
title_sort adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474077/
https://www.ncbi.nlm.nih.gov/pubmed/34604014
http://dx.doi.org/10.5339/qmj.2021.34
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