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Haloperidol Metabolite II Valproate Ester (S)-(−)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma

[Image: see text] Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults. (±)-MRJF22, a prodrug of the sigma (σ) ligand haloperidol metabolite II conjugated with t...

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Detalles Bibliográficos
Autores principales:	Barbaraci, Carla, Giurdanella, Giovanni, Leotta, Claudia Giovanna, Longo, Anna, Amata, Emanuele, Dichiara, Maria, Pasquinucci, Lorella, Turnaturi, Rita, Prezzavento, Orazio, Cacciatore, Ivana, Zuccarello, Elisa, Lupo, Gabriella, Pitari, Giovanni Mario, Anfuso, Carmelina Daniela, Marrazzo, Agostino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474110/ https://www.ncbi.nlm.nih.gov/pubmed/34477381 http://dx.doi.org/10.1021/acs.jmedchem.1c00995

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