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Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer
[Image: see text] We aimed to assess the relationships among the adipose tissue’s (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited wi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474112/ https://www.ncbi.nlm.nih.gov/pubmed/34180659 http://dx.doi.org/10.1021/acs.est.0c08180 |
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author | Mustieles, Vicente Pérez-Carrascosa, Francisco M. León, Josefa Lange, Theis Bonde, Jens-Peter Gómez-Peña, Celia Artacho-Cordón, Francisco Barrios-Rodríguez, Rocío Olmedo-Requena, Rocío Expósito, José Jiménez-Moleón, José J. Arrebola, Juan P. |
author_facet | Mustieles, Vicente Pérez-Carrascosa, Francisco M. León, Josefa Lange, Theis Bonde, Jens-Peter Gómez-Peña, Celia Artacho-Cordón, Francisco Barrios-Rodríguez, Rocío Olmedo-Requena, Rocío Expósito, José Jiménez-Moleón, José J. Arrebola, Juan P. |
author_sort | Mustieles, Vicente |
collection | PubMed |
description | [Image: see text] We aimed to assess the relationships among the adipose tissue’s (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003–2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT’s oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies. |
format | Online Article Text |
id | pubmed-8474112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84741122021-09-28 Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer Mustieles, Vicente Pérez-Carrascosa, Francisco M. León, Josefa Lange, Theis Bonde, Jens-Peter Gómez-Peña, Celia Artacho-Cordón, Francisco Barrios-Rodríguez, Rocío Olmedo-Requena, Rocío Expósito, José Jiménez-Moleón, José J. Arrebola, Juan P. Environ Sci Technol [Image: see text] We aimed to assess the relationships among the adipose tissue’s (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003–2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT’s oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies. American Chemical Society 2021-06-28 2021-07-20 /pmc/articles/PMC8474112/ /pubmed/34180659 http://dx.doi.org/10.1021/acs.est.0c08180 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Mustieles, Vicente Pérez-Carrascosa, Francisco M. León, Josefa Lange, Theis Bonde, Jens-Peter Gómez-Peña, Celia Artacho-Cordón, Francisco Barrios-Rodríguez, Rocío Olmedo-Requena, Rocío Expósito, José Jiménez-Moleón, José J. Arrebola, Juan P. Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer |
title | Adipose
Tissue Redox Microenvironment as a Potential
Link between Persistent Organic Pollutants and the 16-Year Incidence
of Non-hormone-Dependent Cancer |
title_full | Adipose
Tissue Redox Microenvironment as a Potential
Link between Persistent Organic Pollutants and the 16-Year Incidence
of Non-hormone-Dependent Cancer |
title_fullStr | Adipose
Tissue Redox Microenvironment as a Potential
Link between Persistent Organic Pollutants and the 16-Year Incidence
of Non-hormone-Dependent Cancer |
title_full_unstemmed | Adipose
Tissue Redox Microenvironment as a Potential
Link between Persistent Organic Pollutants and the 16-Year Incidence
of Non-hormone-Dependent Cancer |
title_short | Adipose
Tissue Redox Microenvironment as a Potential
Link between Persistent Organic Pollutants and the 16-Year Incidence
of Non-hormone-Dependent Cancer |
title_sort | adipose
tissue redox microenvironment as a potential
link between persistent organic pollutants and the 16-year incidence
of non-hormone-dependent cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474112/ https://www.ncbi.nlm.nih.gov/pubmed/34180659 http://dx.doi.org/10.1021/acs.est.0c08180 |
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