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Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery

[Image: see text] Guanine-rich sequences forming G-quadruplexes (GQs) are present in several genomes, ranging from viral to human. Given their peculiar localization, the induction of GQ formation or GQ stabilization with small molecules represents a strategy for interfering with crucial biological f...

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Detalles Bibliográficos
Autores principales:	Ribaudo, Giovanni, Ongaro, Alberto, Oselladore, Erika, Memo, Maurizio, Gianoncelli, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474113/ https://www.ncbi.nlm.nih.gov/pubmed/34510895 http://dx.doi.org/10.1021/acs.jmedchem.1c00962

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