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Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT(3) and 5-HT(6) Receptor Antagonist with Antipsychotic and Procognitive Properties

[Image: see text] In line with recent clinical trials demonstrating that ondansetron, a 5-HT(3) receptor (5-HT(3)R) antagonist, ameliorates cognitive deficits of schizophrenia and the known procognitive effects of 5-HT(6) receptor (5-HT(6)R) antagonists, we applied the hybridization strategy to desi...

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Autores principales:	Zajdel, Paweł, Grychowska, Katarzyna, Mogilski, Szczepan, Kurczab, Rafał, Satała, Grzegorz, Bugno, Ryszard, Kos, Tomasz, Gołębiowska, Joanna, Malikowska-Racia, Natalia, Nikiforuk, Agnieszka, Chaumont-Dubel, Séverine, Bantreil, Xavier, Pawłowski, Maciej, Martinez, Jean, Subra, Gilles, Lamaty, Frédéric, Marin, Philippe, Bojarski, Andrzej J., Popik, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474115/ https://www.ncbi.nlm.nih.gov/pubmed/34467765 http://dx.doi.org/10.1021/acs.jmedchem.1c00224

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