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Phase 1b Open-Label Trial of Afatinib Plus Xentuzumab (BI 836845) in Patients With EGFR Mutation-Positive NSCLC After Progression on EGFR Tyrosine Kinase Inhibitors

INTRODUCTION: Insulin-like growth factor signaling has been implicated in acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC. This phase 1 trial (NCT02191891) investigated the combination of xentuzumab (an insulin-like growth factor-ligand neutralizing monoclonal antibody) and af...

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Detalles Bibliográficos
Autores principales:	Park, Keunchil, Tan, Daniel Shao Weng, Su, Wu-Chou, Cho, Byoung Chul, Kim, Sang-We, Lee, Ki Hyeong, Wang, Chin-Chou, Seto, Takashi, Huang, Dennis Chin-Lun, Jung, Helen Hayoun, Hsu, Ming-Chi, Bogenrieder, Thomas, Lin, Chia-Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474216/ https://www.ncbi.nlm.nih.gov/pubmed/34590052 http://dx.doi.org/10.1016/j.jtocrr.2021.100206

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