Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report

Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D(3) overproduction from a high-grade fetal lung adenocarcino...

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Detalles Bibliográficos
Autores principales: Saito, Tomohito, Ishida, Mistuaki, Kusabe, Makiko, Utsumi, Takahiro, Maru, Natsumi, Matsui, Hiroshi, Taniguchi, Yohei, Kurata, Takayasu, Kurokawa, Hiroaki, Imada, Takanobu, Tsuta, Koji, Tsukaguchi, Hiroyasu, Murakawa, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474218/
https://www.ncbi.nlm.nih.gov/pubmed/34590047
http://dx.doi.org/10.1016/j.jtocrr.2021.100204
Descripción
Sumario:Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D(3) overproduction from a high-grade fetal lung adenocarcinoma. Histologically, the tumor itself and tumor-adjacent macrophages were positive for the CYP27B1 protein, a key enzyme that generates 1,25-dihydroxyvitamin D(3). Suppression was observed in serum PTH and PTH-related hormone levels, suggesting hypercalcemia is independent of the PTH pathway. Serum calcium level returned to normal after surgical resection of the lung cancer, supporting extrarenal overproduction of 1,25-dihydroxyvitamin D(3) elicited by the tumors is the cause of hypercalcemia in this patient.

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