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Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report

Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D(3) overproduction from a high-grade fetal lung adenocarcino...

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Autores principales: Saito, Tomohito, Ishida, Mistuaki, Kusabe, Makiko, Utsumi, Takahiro, Maru, Natsumi, Matsui, Hiroshi, Taniguchi, Yohei, Kurata, Takayasu, Kurokawa, Hiroaki, Imada, Takanobu, Tsuta, Koji, Tsukaguchi, Hiroyasu, Murakawa, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474218/
https://www.ncbi.nlm.nih.gov/pubmed/34590047
http://dx.doi.org/10.1016/j.jtocrr.2021.100204
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author Saito, Tomohito
Ishida, Mistuaki
Kusabe, Makiko
Utsumi, Takahiro
Maru, Natsumi
Matsui, Hiroshi
Taniguchi, Yohei
Kurata, Takayasu
Kurokawa, Hiroaki
Imada, Takanobu
Tsuta, Koji
Tsukaguchi, Hiroyasu
Murakawa, Tomohiro
author_facet Saito, Tomohito
Ishida, Mistuaki
Kusabe, Makiko
Utsumi, Takahiro
Maru, Natsumi
Matsui, Hiroshi
Taniguchi, Yohei
Kurata, Takayasu
Kurokawa, Hiroaki
Imada, Takanobu
Tsuta, Koji
Tsukaguchi, Hiroyasu
Murakawa, Tomohiro
author_sort Saito, Tomohito
collection PubMed
description Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D(3) overproduction from a high-grade fetal lung adenocarcinoma. Histologically, the tumor itself and tumor-adjacent macrophages were positive for the CYP27B1 protein, a key enzyme that generates 1,25-dihydroxyvitamin D(3). Suppression was observed in serum PTH and PTH-related hormone levels, suggesting hypercalcemia is independent of the PTH pathway. Serum calcium level returned to normal after surgical resection of the lung cancer, supporting extrarenal overproduction of 1,25-dihydroxyvitamin D(3) elicited by the tumors is the cause of hypercalcemia in this patient.
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spelling pubmed-84742182021-09-28 Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report Saito, Tomohito Ishida, Mistuaki Kusabe, Makiko Utsumi, Takahiro Maru, Natsumi Matsui, Hiroshi Taniguchi, Yohei Kurata, Takayasu Kurokawa, Hiroaki Imada, Takanobu Tsuta, Koji Tsukaguchi, Hiroyasu Murakawa, Tomohiro JTO Clin Res Rep Case Report Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D(3) overproduction from a high-grade fetal lung adenocarcinoma. Histologically, the tumor itself and tumor-adjacent macrophages were positive for the CYP27B1 protein, a key enzyme that generates 1,25-dihydroxyvitamin D(3). Suppression was observed in serum PTH and PTH-related hormone levels, suggesting hypercalcemia is independent of the PTH pathway. Serum calcium level returned to normal after surgical resection of the lung cancer, supporting extrarenal overproduction of 1,25-dihydroxyvitamin D(3) elicited by the tumors is the cause of hypercalcemia in this patient. Elsevier 2021-07-05 /pmc/articles/PMC8474218/ /pubmed/34590047 http://dx.doi.org/10.1016/j.jtocrr.2021.100204 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saito, Tomohito
Ishida, Mistuaki
Kusabe, Makiko
Utsumi, Takahiro
Maru, Natsumi
Matsui, Hiroshi
Taniguchi, Yohei
Kurata, Takayasu
Kurokawa, Hiroaki
Imada, Takanobu
Tsuta, Koji
Tsukaguchi, Hiroyasu
Murakawa, Tomohiro
Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report
title Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report
title_full Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report
title_fullStr Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report
title_full_unstemmed Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report
title_short Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D(3) in Fetal Lung Adenocarcinoma: Case Report
title_sort hypercalcemia owing to overproduction of 1,25-dihydroxyvitamin d(3) in fetal lung adenocarcinoma: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474218/
https://www.ncbi.nlm.nih.gov/pubmed/34590047
http://dx.doi.org/10.1016/j.jtocrr.2021.100204
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