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Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report
Immune checkpoint inhibitors (ICIs) have improved the clinical outcome of NSCLC. However, immune-related adverse events (irAEs) such as pneumonitis, thyroiditis, and colitis have been reported with the increasing use of ICIs. The diagnosis of irAEs relies on exclusion. With proper management, most p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474266/ https://www.ncbi.nlm.nih.gov/pubmed/34590016 http://dx.doi.org/10.1016/j.jtocrr.2021.100156 |
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author | Shen, Chia-I Yeh, Yi-Chen Chiu, Chao-Hua |
author_facet | Shen, Chia-I Yeh, Yi-Chen Chiu, Chao-Hua |
author_sort | Shen, Chia-I |
collection | PubMed |
description | Immune checkpoint inhibitors (ICIs) have improved the clinical outcome of NSCLC. However, immune-related adverse events (irAEs) such as pneumonitis, thyroiditis, and colitis have been reported with the increasing use of ICIs. The diagnosis of irAEs relies on exclusion. With proper management, most patients may still benefit from ICI treatment. Pleural effusion is a rare presentation of an irAE. Here, we report a patient who experienced progressive bilateral pleural effusions during the first-line treatment of cisplatin, pemetrexed, and pembrolizumab. Serial study and surgical pleural biopsy found the possible cause of irAE. His pleural effusion subsided after discontinuing therapy. IrAE may present as pleural effusion and physicians should be alert to unknown causes of pleural effusion in patients under ICI treatment. |
format | Online Article Text |
id | pubmed-8474266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84742662021-09-28 Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report Shen, Chia-I Yeh, Yi-Chen Chiu, Chao-Hua JTO Clin Res Rep Case Report Immune checkpoint inhibitors (ICIs) have improved the clinical outcome of NSCLC. However, immune-related adverse events (irAEs) such as pneumonitis, thyroiditis, and colitis have been reported with the increasing use of ICIs. The diagnosis of irAEs relies on exclusion. With proper management, most patients may still benefit from ICI treatment. Pleural effusion is a rare presentation of an irAE. Here, we report a patient who experienced progressive bilateral pleural effusions during the first-line treatment of cisplatin, pemetrexed, and pembrolizumab. Serial study and surgical pleural biopsy found the possible cause of irAE. His pleural effusion subsided after discontinuing therapy. IrAE may present as pleural effusion and physicians should be alert to unknown causes of pleural effusion in patients under ICI treatment. Elsevier 2021-02-17 /pmc/articles/PMC8474266/ /pubmed/34590016 http://dx.doi.org/10.1016/j.jtocrr.2021.100156 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Shen, Chia-I Yeh, Yi-Chen Chiu, Chao-Hua Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report |
title | Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report |
title_full | Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report |
title_fullStr | Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report |
title_full_unstemmed | Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report |
title_short | Progressive Pleural Effusion as an Immune-Related Adverse Event in NSCLC: A Case Report |
title_sort | progressive pleural effusion as an immune-related adverse event in nsclc: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474266/ https://www.ncbi.nlm.nih.gov/pubmed/34590016 http://dx.doi.org/10.1016/j.jtocrr.2021.100156 |
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