Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

BACKGROUND: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. OBJECTIVE: The objective of the study is to provide an estimated RIS prevalence in a population-based c...

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Autores principales: de Mol, CL, Bruijstens, AL, Jansen, PR, Dremmen, MHG, Wong, YYM, van der Lugt, A, White, TJH, Neuteboom, RF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474308/
https://www.ncbi.nlm.nih.gov/pubmed/33480814
http://dx.doi.org/10.1177/1352458521989220
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author de Mol, CL
Bruijstens, AL
Jansen, PR
Dremmen, MHG
Wong, YYM
van der Lugt, A
White, TJH
Neuteboom, RF
author_facet de Mol, CL
Bruijstens, AL
Jansen, PR
Dremmen, MHG
Wong, YYM
van der Lugt, A
White, TJH
Neuteboom, RF
author_sort de Mol, CL
collection PubMed
description BACKGROUND: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. OBJECTIVE: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. METHODS: We used data from the Generation R study to identify the childhood RIS prevalence. RESULTS: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. CONCLUSIONS: This study shows that the occurrence of RIS in children from the general population is rare.
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spelling pubmed-84743082021-09-28 Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis de Mol, CL Bruijstens, AL Jansen, PR Dremmen, MHG Wong, YYM van der Lugt, A White, TJH Neuteboom, RF Mult Scler Short Reports BACKGROUND: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. OBJECTIVE: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. METHODS: We used data from the Generation R study to identify the childhood RIS prevalence. RESULTS: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. CONCLUSIONS: This study shows that the occurrence of RIS in children from the general population is rare. SAGE Publications 2021-01-22 2021-10 /pmc/articles/PMC8474308/ /pubmed/33480814 http://dx.doi.org/10.1177/1352458521989220 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Reports
de Mol, CL
Bruijstens, AL
Jansen, PR
Dremmen, MHG
Wong, YYM
van der Lugt, A
White, TJH
Neuteboom, RF
Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
title Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
title_full Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
title_fullStr Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
title_full_unstemmed Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
title_short Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
title_sort prevalence of radiologically isolated syndrome in a pediatric population-based cohort: a longitudinal description of a rare diagnosis
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474308/
https://www.ncbi.nlm.nih.gov/pubmed/33480814
http://dx.doi.org/10.1177/1352458521989220
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