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EML4-ALK Rearrangement as a Mechanism of Resistance to Osimertinib in Metastatic Lung Adenocarcinoma: A Case Report

Osimertinib, a third-generation EGFR tyrosine kinase inhibitor, is the preferred frontline therapy for EGFR-mutant advanced NSCLC. However, despite its high initial response rates, multiple EGFR-independent mechanisms of resistance have been reported in patients receiving osimertinib. One such mecha...

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Detalles Bibliográficos
Autores principales:	von Buttlar, Xinyu, Reuss, Joshua E., Liu, Stephen V., Kim, Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474351/ https://www.ncbi.nlm.nih.gov/pubmed/34590027 http://dx.doi.org/10.1016/j.jtocrr.2021.100179

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