Cargando…
A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients
Neuroinflammation occurs in response to acute ischemic stroke, and has been speculated to underlie secondary poststroke pathologies, such as depression, that often develop over time poststroke. However, no study has examined whether neuroinflammation is present in chronic stroke patients (e.g., ≥ ...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474408/ https://www.ncbi.nlm.nih.gov/pubmed/34589819 http://dx.doi.org/10.1016/j.bbih.2021.100336 |
_version_ | 1784575211937464320 |
---|---|
author | Schaechter, Judith D. Hightower, Baileigh G. Kim, Minhae Loggia, Marco L. |
author_facet | Schaechter, Judith D. Hightower, Baileigh G. Kim, Minhae Loggia, Marco L. |
author_sort | Schaechter, Judith D. |
collection | PubMed |
description | Neuroinflammation occurs in response to acute ischemic stroke, and has been speculated to underlie secondary poststroke pathologies, such as depression, that often develop over time poststroke. However, no study has examined whether neuroinflammation is present in chronic stroke patients (e.g., ≥ 1 year poststroke). This study tested whether neuroinflammation is present in chronic stroke patients, and is associated with neurodegeneration, using [(11)C]PBR28 PET and diffusion MRI. Eight patients with middle cerebral artery (MCA) ischemic stroke incurred 1–3 years prior and 16 healthy controls underwent [(11)C]PBR28 PET to measure glial activation and diffusion MRI to measure microstructural integrity by mean diffusivity (MD) and fractional anisotropy (FA) using an integrated PET/MRI scanner. Group differences in [(11)C]PBR28 binding, MD and FA were analyzed voxelwise across the whole brain excluding the infarct zone defined as voxels containing the infarct in any patient. Compared to controls, patients showed elevations in [(11)C]PBR28 binding in several brain regions outside the infarct zone, including regions with presumed direct neuroanatomical connections to the infarct (e.g., ipsilesional internal capsule and thalamus) and those without known direct connections (e.g., contralesional thalamus and cingulate gyrus). Patients also showed widespread elevations in MD, with a subset of these regions having reduced FA. In patients, MD was more elevated in regions with co-localized elevations in [(11)C]PBR28 binding than in contralateral regions without elevations in [(11)C]PBR28 binding. This pilot study supports the presence of extensive glial activation along with widespread loss in microstructural integrity in non-infarcted tissue in a cohort of patients with chronic MCA stroke. The loss in microstructural integrity was greater in regions with co-localized glial activation. It is possible that stroke risk factors (e.g., hypertension) contributed to these tissue changes in patients. |
format | Online Article Text |
id | pubmed-8474408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84744082021-09-28 A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients Schaechter, Judith D. Hightower, Baileigh G. Kim, Minhae Loggia, Marco L. Brain Behav Immun Health Full Length Article Neuroinflammation occurs in response to acute ischemic stroke, and has been speculated to underlie secondary poststroke pathologies, such as depression, that often develop over time poststroke. However, no study has examined whether neuroinflammation is present in chronic stroke patients (e.g., ≥ 1 year poststroke). This study tested whether neuroinflammation is present in chronic stroke patients, and is associated with neurodegeneration, using [(11)C]PBR28 PET and diffusion MRI. Eight patients with middle cerebral artery (MCA) ischemic stroke incurred 1–3 years prior and 16 healthy controls underwent [(11)C]PBR28 PET to measure glial activation and diffusion MRI to measure microstructural integrity by mean diffusivity (MD) and fractional anisotropy (FA) using an integrated PET/MRI scanner. Group differences in [(11)C]PBR28 binding, MD and FA were analyzed voxelwise across the whole brain excluding the infarct zone defined as voxels containing the infarct in any patient. Compared to controls, patients showed elevations in [(11)C]PBR28 binding in several brain regions outside the infarct zone, including regions with presumed direct neuroanatomical connections to the infarct (e.g., ipsilesional internal capsule and thalamus) and those without known direct connections (e.g., contralesional thalamus and cingulate gyrus). Patients also showed widespread elevations in MD, with a subset of these regions having reduced FA. In patients, MD was more elevated in regions with co-localized elevations in [(11)C]PBR28 binding than in contralateral regions without elevations in [(11)C]PBR28 binding. This pilot study supports the presence of extensive glial activation along with widespread loss in microstructural integrity in non-infarcted tissue in a cohort of patients with chronic MCA stroke. The loss in microstructural integrity was greater in regions with co-localized glial activation. It is possible that stroke risk factors (e.g., hypertension) contributed to these tissue changes in patients. Elsevier 2021-08-24 /pmc/articles/PMC8474408/ /pubmed/34589819 http://dx.doi.org/10.1016/j.bbih.2021.100336 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Full Length Article Schaechter, Judith D. Hightower, Baileigh G. Kim, Minhae Loggia, Marco L. A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients |
title | A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients |
title_full | A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients |
title_fullStr | A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients |
title_full_unstemmed | A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients |
title_short | A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients |
title_sort | pilot [(11)c]pbr28 pet/mri study of neuroinflammation and neurodegeneration in chronic stroke patients |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474408/ https://www.ncbi.nlm.nih.gov/pubmed/34589819 http://dx.doi.org/10.1016/j.bbih.2021.100336 |
work_keys_str_mv | AT schaechterjudithd apilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT hightowerbaileighg apilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT kimminhae apilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT loggiamarcol apilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT schaechterjudithd pilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT hightowerbaileighg pilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT kimminhae pilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients AT loggiamarcol pilot11cpbr28petmristudyofneuroinflammationandneurodegenerationinchronicstrokepatients |