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Subacute metformin treatment reduces inflammation and improves functional outcome following neonatal hypoxia ischemia

Hypoxia-ischemia (HI) injury is a leading cause of neonatal death and long-term disability, and existing treatment options for HI offer only modest benefit. Early intervention with the drug metformin has been shown to promote functional improvement in numerous rodent models of injury and has pleiotr...

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Detalles Bibliográficos
Autores principales: Livingston, Jessica M., Syeda, Tasfia, Christie, Taryn, Gilbert, Emily A.B., Morshead, Cindi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474427/
https://www.ncbi.nlm.nih.gov/pubmed/34589876
http://dx.doi.org/10.1016/j.bbih.2020.100119