Cargando…
Subacute metformin treatment reduces inflammation and improves functional outcome following neonatal hypoxia ischemia
Hypoxia-ischemia (HI) injury is a leading cause of neonatal death and long-term disability, and existing treatment options for HI offer only modest benefit. Early intervention with the drug metformin has been shown to promote functional improvement in numerous rodent models of injury and has pleiotr...
Autores principales: | Livingston, Jessica M., Syeda, Tasfia, Christie, Taryn, Gilbert, Emily A.B., Morshead, Cindi M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474427/ https://www.ncbi.nlm.nih.gov/pubmed/34589876 http://dx.doi.org/10.1016/j.bbih.2020.100119 |
Ejemplares similares
-
Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury
por: Gilbert, Emily A B, et al.
Publicado: (2023) -
Stem cell heterogeneity and regenerative competence: the enormous potential of rare cells
por: Gilbert, Emily A.B., et al.
Publicado: (2020) -
Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke
por: Ruddy, Rebecca M., et al.
Publicado: (2019) -
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke
por: Bourget, Clara, et al.
Publicado: (2022) -
Retinal-glia ischemia and inflammation induced by chronic stress: The SABPA study
por: Malan, Leoné, et al.
Publicado: (2019)