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Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers

Social-cognitive difficulties can negatively impact interpersonal communication, shared social experience, and meaningful relationships. This pilot investigation examined the relationship between social-cognitive functioning and inflammatory markers in people with multiple sclerosis (MS) and demogra...

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Autores principales: Turner, Jason A., Padgett, Christine, McDonald, Skye, Ahuja, Kiran D.K., Francis, Heather M., Lim, Chai K., Honan, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474509/
https://www.ncbi.nlm.nih.gov/pubmed/34589763
http://dx.doi.org/10.1016/j.bbih.2021.100254
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author Turner, Jason A.
Padgett, Christine
McDonald, Skye
Ahuja, Kiran D.K.
Francis, Heather M.
Lim, Chai K.
Honan, Cynthia A.
author_facet Turner, Jason A.
Padgett, Christine
McDonald, Skye
Ahuja, Kiran D.K.
Francis, Heather M.
Lim, Chai K.
Honan, Cynthia A.
author_sort Turner, Jason A.
collection PubMed
description Social-cognitive difficulties can negatively impact interpersonal communication, shared social experience, and meaningful relationships. This pilot investigation examined the relationship between social-cognitive functioning and inflammatory markers in people with multiple sclerosis (MS) and demographically-matched healthy individuals. Additionally, we compared the immune marker profile in serum and urine-matched samples. Social cognitive functioning was objectively assessed using The Awareness of Social Inference Test – Short (TASIT-S) and subjectively assessed using self-reports of abilities in emotion recognition, emotional empathy, and cognitive theory of mind. In people with MS and healthy individuals, there were moderate-to-large negative relationships between pro-inflammatory biomarkers (serum IL-1β, IL-17, TNF-α, IP-10, MIP-1α, and urine IP-10, MIP-1β) of the innate immune system and social-cognitive functioning. In MS, a higher serum concentration of the anti-inflammatory marker IL-1ra was associated with better social-cognitive functioning (i.e., self-reported emotional empathy and TASIT-S sarcasm detection performance). However, there were mixed findings for anti-inflammatory serum markers IL-4 and IL-10. Overall, our findings indicate a relationship between pro-inflammatory cytokines and social-cognitive abilities. Future studies may provide greater insight into biologically-derived inflammatory processes, sickness behaviour, and their connection with social cognition.
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spelling pubmed-84745092021-09-28 Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers Turner, Jason A. Padgett, Christine McDonald, Skye Ahuja, Kiran D.K. Francis, Heather M. Lim, Chai K. Honan, Cynthia A. Brain Behav Immun Health Full Length Article Social-cognitive difficulties can negatively impact interpersonal communication, shared social experience, and meaningful relationships. This pilot investigation examined the relationship between social-cognitive functioning and inflammatory markers in people with multiple sclerosis (MS) and demographically-matched healthy individuals. Additionally, we compared the immune marker profile in serum and urine-matched samples. Social cognitive functioning was objectively assessed using The Awareness of Social Inference Test – Short (TASIT-S) and subjectively assessed using self-reports of abilities in emotion recognition, emotional empathy, and cognitive theory of mind. In people with MS and healthy individuals, there were moderate-to-large negative relationships between pro-inflammatory biomarkers (serum IL-1β, IL-17, TNF-α, IP-10, MIP-1α, and urine IP-10, MIP-1β) of the innate immune system and social-cognitive functioning. In MS, a higher serum concentration of the anti-inflammatory marker IL-1ra was associated with better social-cognitive functioning (i.e., self-reported emotional empathy and TASIT-S sarcasm detection performance). However, there were mixed findings for anti-inflammatory serum markers IL-4 and IL-10. Overall, our findings indicate a relationship between pro-inflammatory cytokines and social-cognitive abilities. Future studies may provide greater insight into biologically-derived inflammatory processes, sickness behaviour, and their connection with social cognition. Elsevier 2021-04-14 /pmc/articles/PMC8474509/ /pubmed/34589763 http://dx.doi.org/10.1016/j.bbih.2021.100254 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Turner, Jason A.
Padgett, Christine
McDonald, Skye
Ahuja, Kiran D.K.
Francis, Heather M.
Lim, Chai K.
Honan, Cynthia A.
Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
title Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
title_full Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
title_fullStr Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
title_full_unstemmed Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
title_short Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
title_sort innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: implications for il-1ra and urinary immune markers
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474509/
https://www.ncbi.nlm.nih.gov/pubmed/34589763
http://dx.doi.org/10.1016/j.bbih.2021.100254
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