Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation

Uptake transporters in brain microvascular endothelial cells (BMECs) are involved in the penetration of basic (cationic) drugs such as diphenhydramine (DPHM) into the brain. Lipopolysaccharide (LPS)-induced inflammation alters the expression levels and activities of uptake transporters, which change...

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Detalles Bibliográficos
Autores principales: Kawase, Atsushi, Chuma, Taihei, Irie, Kota, Kazaoka, Akira, Kakuno, Asuka, Matsuda, Naoya, Shimada, Hiroaki, Iwaki, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474606/
https://www.ncbi.nlm.nih.gov/pubmed/34589723
http://dx.doi.org/10.1016/j.bbih.2020.100188

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