Cargando…
Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer
Previously regarded as simple fat storage particles, new evidence suggests that lipid droplets (LDs) are dynamic and functional organelles involved in key cellular processes such as membrane biosynthesis, lipid metabolism, cell signalling and inflammation. Indeed, an increased LD content is one of t...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474722/ https://www.ncbi.nlm.nih.gov/pubmed/34630864 http://dx.doi.org/10.4252/wjsc.v13.i9.1307 |
_version_ | 1784575280691544064 |
---|---|
author | Royo-García, Alba Courtois, Sarah Parejo-Alonso, Beatriz Espiau-Romera, Pilar Sancho, Patricia |
author_facet | Royo-García, Alba Courtois, Sarah Parejo-Alonso, Beatriz Espiau-Romera, Pilar Sancho, Patricia |
author_sort | Royo-García, Alba |
collection | PubMed |
description | Previously regarded as simple fat storage particles, new evidence suggests that lipid droplets (LDs) are dynamic and functional organelles involved in key cellular processes such as membrane biosynthesis, lipid metabolism, cell signalling and inflammation. Indeed, an increased LD content is one of the most apparent features resulting from lipid metabolism reprogramming necessary to support the basic functions of cancer cells. LDs have been associated to different cellular processes involved in cancer progression and aggressiveness, such as tumorigenicity, invasion and metastasis, as well as chemoresistance. Interestingly, all of these processes are controlled by a subpopulation of highly aggressive tumoral cells named cancer stem cells (CSCs), suggesting that LDs may be fundamental elements for stemness in cancer. Considering the key role of CSCs on chemoresistance and disease relapse, main factors of therapy failure, the design of novel therapeutic approaches targeting these cells may be the only chance for long-term survival in cancer patients. In this sense, their biology and functional properties render LDs excellent candidates for target discovery and design of combined therapeutic strategies. In this review, we summarise the current knowledge identifying LDs and CSCs as main contributors to cancer aggressiveness, metastasis and chemoresistance. |
format | Online Article Text |
id | pubmed-8474722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-84747222021-10-08 Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer Royo-García, Alba Courtois, Sarah Parejo-Alonso, Beatriz Espiau-Romera, Pilar Sancho, Patricia World J Stem Cells Minireviews Previously regarded as simple fat storage particles, new evidence suggests that lipid droplets (LDs) are dynamic and functional organelles involved in key cellular processes such as membrane biosynthesis, lipid metabolism, cell signalling and inflammation. Indeed, an increased LD content is one of the most apparent features resulting from lipid metabolism reprogramming necessary to support the basic functions of cancer cells. LDs have been associated to different cellular processes involved in cancer progression and aggressiveness, such as tumorigenicity, invasion and metastasis, as well as chemoresistance. Interestingly, all of these processes are controlled by a subpopulation of highly aggressive tumoral cells named cancer stem cells (CSCs), suggesting that LDs may be fundamental elements for stemness in cancer. Considering the key role of CSCs on chemoresistance and disease relapse, main factors of therapy failure, the design of novel therapeutic approaches targeting these cells may be the only chance for long-term survival in cancer patients. In this sense, their biology and functional properties render LDs excellent candidates for target discovery and design of combined therapeutic strategies. In this review, we summarise the current knowledge identifying LDs and CSCs as main contributors to cancer aggressiveness, metastasis and chemoresistance. Baishideng Publishing Group Inc 2021-09-26 2021-09-26 /pmc/articles/PMC8474722/ /pubmed/34630864 http://dx.doi.org/10.4252/wjsc.v13.i9.1307 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Royo-García, Alba Courtois, Sarah Parejo-Alonso, Beatriz Espiau-Romera, Pilar Sancho, Patricia Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
title | Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
title_full | Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
title_fullStr | Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
title_full_unstemmed | Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
title_short | Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
title_sort | lipid droplets as metabolic determinants for stemness and chemoresistance in cancer |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474722/ https://www.ncbi.nlm.nih.gov/pubmed/34630864 http://dx.doi.org/10.4252/wjsc.v13.i9.1307 |
work_keys_str_mv | AT royogarciaalba lipiddropletsasmetabolicdeterminantsforstemnessandchemoresistanceincancer AT courtoissarah lipiddropletsasmetabolicdeterminantsforstemnessandchemoresistanceincancer AT parejoalonsobeatriz lipiddropletsasmetabolicdeterminantsforstemnessandchemoresistanceincancer AT espiauromerapilar lipiddropletsasmetabolicdeterminantsforstemnessandchemoresistanceincancer AT sanchopatricia lipiddropletsasmetabolicdeterminantsforstemnessandchemoresistanceincancer |