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Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI

BACKGROUND: The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats. METHODS: Forty-eight Sprague-Dawley (SD) rats were divided into a control group and a diabetic mellitus (DM) group. Six rats...

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Autores principales: Feng, You-Zhen, Chen, Xiao-Qiao, Cheng, Zhong-Yuan, Lin, Qi-Ting, Chen, Ping-Kang, Si-Tu, Ding-Kun, Cao, Rui, Qian, Long, Heng, Baoli, Cai, Xiang-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474753/
https://www.ncbi.nlm.nih.gov/pubmed/34565330
http://dx.doi.org/10.1186/s12882-021-02530-8
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author Feng, You-Zhen
Chen, Xiao-Qiao
Cheng, Zhong-Yuan
Lin, Qi-Ting
Chen, Ping-Kang
Si-Tu, Ding-Kun
Cao, Rui
Qian, Long
Heng, Baoli
Cai, Xiang-Ran
author_facet Feng, You-Zhen
Chen, Xiao-Qiao
Cheng, Zhong-Yuan
Lin, Qi-Ting
Chen, Ping-Kang
Si-Tu, Ding-Kun
Cao, Rui
Qian, Long
Heng, Baoli
Cai, Xiang-Ran
author_sort Feng, You-Zhen
collection PubMed
description BACKGROUND: The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats. METHODS: Forty-eight Sprague-Dawley (SD) rats were divided into a control group and a diabetic mellitus (DM) group. Six rats in each group were randomly selected for MR scans at four different time points (0, 4, 8, and 12 weeks). The IVIM-derived parameters (D, D*, f and ADC values) of the renal cortex (CO), outer and inner stripe of the outer medulla (OS, IS), and internal medulla (IM) were acquired. Changes in each IVIM-derived parameter over time were analyzed, and differences between the two groups at each point were assessed. The associations between the IVIM parameters and IV collagen expression, urine volume (UV), blood urea nitrogen (BUN), and serum creatinine (Scr) were investigated. RESULTS: The D and D* values of CO and the ADC values of CO, OS, IS and IM displayed significantly different trends between the two groups over time (P<0.05). In addition, significant correlations were discovered between the D* value of CO and UV and BUN (r=0.527, P=0.033; r=0.617, P=0.005), between the ADC value of IM and BUN (r=0.557, P=0.019) and between the f value of IM and BUN (r=0.527, P=0.033). No correlation was found between IVIM parameters and IV collagen expression and Scr. CONCLUSIONS: IVIM is a potential sensitive and noninvasive technology for the simultaneous assessment of early renal cortical and medullary injuries induced by diabetes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02530-8.
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spelling pubmed-84747532021-09-28 Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI Feng, You-Zhen Chen, Xiao-Qiao Cheng, Zhong-Yuan Lin, Qi-Ting Chen, Ping-Kang Si-Tu, Ding-Kun Cao, Rui Qian, Long Heng, Baoli Cai, Xiang-Ran BMC Nephrol Research Article BACKGROUND: The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats. METHODS: Forty-eight Sprague-Dawley (SD) rats were divided into a control group and a diabetic mellitus (DM) group. Six rats in each group were randomly selected for MR scans at four different time points (0, 4, 8, and 12 weeks). The IVIM-derived parameters (D, D*, f and ADC values) of the renal cortex (CO), outer and inner stripe of the outer medulla (OS, IS), and internal medulla (IM) were acquired. Changes in each IVIM-derived parameter over time were analyzed, and differences between the two groups at each point were assessed. The associations between the IVIM parameters and IV collagen expression, urine volume (UV), blood urea nitrogen (BUN), and serum creatinine (Scr) were investigated. RESULTS: The D and D* values of CO and the ADC values of CO, OS, IS and IM displayed significantly different trends between the two groups over time (P<0.05). In addition, significant correlations were discovered between the D* value of CO and UV and BUN (r=0.527, P=0.033; r=0.617, P=0.005), between the ADC value of IM and BUN (r=0.557, P=0.019) and between the f value of IM and BUN (r=0.527, P=0.033). No correlation was found between IVIM parameters and IV collagen expression and Scr. CONCLUSIONS: IVIM is a potential sensitive and noninvasive technology for the simultaneous assessment of early renal cortical and medullary injuries induced by diabetes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02530-8. BioMed Central 2021-09-26 /pmc/articles/PMC8474753/ /pubmed/34565330 http://dx.doi.org/10.1186/s12882-021-02530-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Feng, You-Zhen
Chen, Xiao-Qiao
Cheng, Zhong-Yuan
Lin, Qi-Ting
Chen, Ping-Kang
Si-Tu, Ding-Kun
Cao, Rui
Qian, Long
Heng, Baoli
Cai, Xiang-Ran
Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
title Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
title_full Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
title_fullStr Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
title_full_unstemmed Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
title_short Non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (IVIM) MRI
title_sort non-invasive investigation of early kidney damage in streptozotocin-induced diabetic rats by intravoxel incoherent motion diffusion-weighted (ivim) mri
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474753/
https://www.ncbi.nlm.nih.gov/pubmed/34565330
http://dx.doi.org/10.1186/s12882-021-02530-8
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