Cargando…

Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients

BACKGROUND: Psoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis. METHODS: A total of 477 patients with psoriasis vulgaris (PsV, n = 347), generalized pustular psoriasis (GPP, n = 37), erythrodermic psoriasis (PsE, n = 4...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wen-Ming, Wu, Chao, Gao, Yi-Meng, Li, Feng, Yu, Xiao-Ling, Jin, Hong-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474773/
https://www.ncbi.nlm.nih.gov/pubmed/34565327
http://dx.doi.org/10.1186/s12865-021-00454-4
_version_ 1784575293765189632
author Wang, Wen-Ming
Wu, Chao
Gao, Yi-Meng
Li, Feng
Yu, Xiao-Ling
Jin, Hong-Zhong
author_facet Wang, Wen-Ming
Wu, Chao
Gao, Yi-Meng
Li, Feng
Yu, Xiao-Ling
Jin, Hong-Zhong
author_sort Wang, Wen-Ming
collection PubMed
description BACKGROUND: Psoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis. METHODS: A total of 477 patients with psoriasis vulgaris (PsV, n = 347), generalized pustular psoriasis (GPP, n = 37), erythrodermic psoriasis (PsE, n = 45), arthritic psoriasis (PsA, n = 25) and mixed psoriasis (n = 23), and 954 healthy control subjects were included in the study. Demographic, clinical, and laboratory information were collected and compared between subgroups. RESULTS: Compared with the healthy control group, patients with psoriasis had higher total white blood cell (WBC), neutrophil, platelet counts, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR), but lower hemoglobin (Hb) levels, lymphocyte and red blood cell (RBC) counts. NLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups, with GPP group being the highest. PLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups. There was no significant correlation between the psoriasis area severity index (PASI) score and either the NLR or PLR in the PsV group. CONCLUSIONS: Elevated NLR and PLR were associated with psoriasis and differed between subtypes, suggesting that they could be used as markers of systemic inflammation in psoriasis patients.
format Online
Article
Text
id pubmed-8474773
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-84747732021-09-28 Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients Wang, Wen-Ming Wu, Chao Gao, Yi-Meng Li, Feng Yu, Xiao-Ling Jin, Hong-Zhong BMC Immunol Research Article BACKGROUND: Psoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis. METHODS: A total of 477 patients with psoriasis vulgaris (PsV, n = 347), generalized pustular psoriasis (GPP, n = 37), erythrodermic psoriasis (PsE, n = 45), arthritic psoriasis (PsA, n = 25) and mixed psoriasis (n = 23), and 954 healthy control subjects were included in the study. Demographic, clinical, and laboratory information were collected and compared between subgroups. RESULTS: Compared with the healthy control group, patients with psoriasis had higher total white blood cell (WBC), neutrophil, platelet counts, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR), but lower hemoglobin (Hb) levels, lymphocyte and red blood cell (RBC) counts. NLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups, with GPP group being the highest. PLR values in the PsV group were significantly lower than those in the GPP, PsE, and PsA groups. There was no significant correlation between the psoriasis area severity index (PASI) score and either the NLR or PLR in the PsV group. CONCLUSIONS: Elevated NLR and PLR were associated with psoriasis and differed between subtypes, suggesting that they could be used as markers of systemic inflammation in psoriasis patients. BioMed Central 2021-09-26 /pmc/articles/PMC8474773/ /pubmed/34565327 http://dx.doi.org/10.1186/s12865-021-00454-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Wang, Wen-Ming
Wu, Chao
Gao, Yi-Meng
Li, Feng
Yu, Xiao-Ling
Jin, Hong-Zhong
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
title Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
title_full Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
title_fullStr Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
title_full_unstemmed Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
title_short Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
title_sort neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and other hematological parameters in psoriasis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474773/
https://www.ncbi.nlm.nih.gov/pubmed/34565327
http://dx.doi.org/10.1186/s12865-021-00454-4
work_keys_str_mv AT wangwenming neutrophiltolymphocyteratioplatelettolymphocyteratioandotherhematologicalparametersinpsoriasispatients
AT wuchao neutrophiltolymphocyteratioplatelettolymphocyteratioandotherhematologicalparametersinpsoriasispatients
AT gaoyimeng neutrophiltolymphocyteratioplatelettolymphocyteratioandotherhematologicalparametersinpsoriasispatients
AT lifeng neutrophiltolymphocyteratioplatelettolymphocyteratioandotherhematologicalparametersinpsoriasispatients
AT yuxiaoling neutrophiltolymphocyteratioplatelettolymphocyteratioandotherhematologicalparametersinpsoriasispatients
AT jinhongzhong neutrophiltolymphocyteratioplatelettolymphocyteratioandotherhematologicalparametersinpsoriasispatients