Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation

BACKGROUND: Mammalian development is associated with extensive changes in gene expression, chromatin accessibility, and nuclear structure. Here, we follow such changes associated with mouse embryonic stem cell differentiation and X inactivation by integrating, for the first time, allele-specific dat...

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Detalles Bibliográficos
Autores principales: Bonora, Giancarlo, Ramani, Vijay, Singh, Ritambhara, Fang, He, Jackson, Dana L., Srivatsan, Sanjay, Qiu, Ruolan, Lee, Choli, Trapnell, Cole, Shendure, Jay, Duan, Zhijun, Deng, Xinxian, Noble, William S., Disteche, Christine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474932/
https://www.ncbi.nlm.nih.gov/pubmed/34579774
http://dx.doi.org/10.1186/s13059-021-02432-w

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