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Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis

BACKGROUND: Recent trials have shown that low‐density lipoprotein cholesterol (LDL‐C) <1.80 mmol/L (<70 mg/dL) is associated with a reduced risk of major adverse cardiovascular events in White patients with ischemic stroke with atherosclerosis. However, it remains uncertain whether the finding...

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Autores principales: Lau, Kui‐Kai, Chua, Bryan J., Ng, Alexander, Leung, Ian Yu‐Hin, Wong, Yuen‐Kwun, Chan, Anna Ho‐Yin, Chiu, Yuen‐Kei, Chu, Ariane Xia‐Wei, Leung, William C. Y., Tsang, Anderson Chun‐On, Teo, Kay‐Cheong, Mak, Henry Ka‐Fung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475056/
https://www.ncbi.nlm.nih.gov/pubmed/34369170
http://dx.doi.org/10.1161/JAHA.121.021855
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author Lau, Kui‐Kai
Chua, Bryan J.
Ng, Alexander
Leung, Ian Yu‐Hin
Wong, Yuen‐Kwun
Chan, Anna Ho‐Yin
Chiu, Yuen‐Kei
Chu, Ariane Xia‐Wei
Leung, William C. Y.
Tsang, Anderson Chun‐On
Teo, Kay‐Cheong
Mak, Henry Ka‐Fung
author_facet Lau, Kui‐Kai
Chua, Bryan J.
Ng, Alexander
Leung, Ian Yu‐Hin
Wong, Yuen‐Kwun
Chan, Anna Ho‐Yin
Chiu, Yuen‐Kei
Chu, Ariane Xia‐Wei
Leung, William C. Y.
Tsang, Anderson Chun‐On
Teo, Kay‐Cheong
Mak, Henry Ka‐Fung
author_sort Lau, Kui‐Kai
collection PubMed
description BACKGROUND: Recent trials have shown that low‐density lipoprotein cholesterol (LDL‐C) <1.80 mmol/L (<70 mg/dL) is associated with a reduced risk of major adverse cardiovascular events in White patients with ischemic stroke with atherosclerosis. However, it remains uncertain whether the findings can be generalized to Asian patients, or that similar LDL‐C targets should be adopted in patients with stroke without significant atherosclerosis. METHODS AND RESULTS: We performed a prospective cohort study and recruited consecutive Chinese patients with ischemic stroke with magnetic resonance angiography of the intra‐ and cervicocranial arteries performed at the University of Hong Kong between 2008 and 2014. Serial postevent LDL‐C measurements were obtained. Risk of major adverse cardiovascular events in patients with mean postevent LDL‐C <1.80 versus ≥1.80 mmol/L, stratified by presence or absence of significant (≥50%) large‐artery disease (LAD) and by ischemic stroke subtypes, were compared. Nine hundred four patients (mean age, 69±12 years; 60% men) were followed up for a mean 6.5±2.4 years (mean, 9±5 LDL‐C readings per patient). Regardless of LAD status, patients with a mean postevent LDL‐C <1.80 mmol/L were associated with a lower risk of major adverse cardiovascular events (with significant LAD: multivariable‐adjusted subdistribution hazard ratio, 0.65; 95% CI, 0.42–0.99; without significant LAD: subdistribution hazard ratio, 0.53; 95% CI, 0.32–0.88) (both P<0.05). Similar findings were noted in patients with ischemic stroke attributable to large‐artery atherosclerosis (subdistribution hazard ratio, 0.48; 95% CI, 0.28–0.84) and in patients with other ischemic stroke subtypes (subdistribution hazard ratio, 0.64; 95% CI, 0.43–0.95) (both P<0.05). CONCLUSIONS: A mean LDL‐C <1.80 mmol/L was associated with a lower risk of major adverse cardiovascular events in Chinese patients with ischemic stroke with and without significant LAD. Further randomized trials to determine the optimal LDL‐C cutoff in stroke patients without significant atherosclerosis are warranted.
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spelling pubmed-84750562021-10-01 Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis Lau, Kui‐Kai Chua, Bryan J. Ng, Alexander Leung, Ian Yu‐Hin Wong, Yuen‐Kwun Chan, Anna Ho‐Yin Chiu, Yuen‐Kei Chu, Ariane Xia‐Wei Leung, William C. Y. Tsang, Anderson Chun‐On Teo, Kay‐Cheong Mak, Henry Ka‐Fung J Am Heart Assoc Original Research BACKGROUND: Recent trials have shown that low‐density lipoprotein cholesterol (LDL‐C) <1.80 mmol/L (<70 mg/dL) is associated with a reduced risk of major adverse cardiovascular events in White patients with ischemic stroke with atherosclerosis. However, it remains uncertain whether the findings can be generalized to Asian patients, or that similar LDL‐C targets should be adopted in patients with stroke without significant atherosclerosis. METHODS AND RESULTS: We performed a prospective cohort study and recruited consecutive Chinese patients with ischemic stroke with magnetic resonance angiography of the intra‐ and cervicocranial arteries performed at the University of Hong Kong between 2008 and 2014. Serial postevent LDL‐C measurements were obtained. Risk of major adverse cardiovascular events in patients with mean postevent LDL‐C <1.80 versus ≥1.80 mmol/L, stratified by presence or absence of significant (≥50%) large‐artery disease (LAD) and by ischemic stroke subtypes, were compared. Nine hundred four patients (mean age, 69±12 years; 60% men) were followed up for a mean 6.5±2.4 years (mean, 9±5 LDL‐C readings per patient). Regardless of LAD status, patients with a mean postevent LDL‐C <1.80 mmol/L were associated with a lower risk of major adverse cardiovascular events (with significant LAD: multivariable‐adjusted subdistribution hazard ratio, 0.65; 95% CI, 0.42–0.99; without significant LAD: subdistribution hazard ratio, 0.53; 95% CI, 0.32–0.88) (both P<0.05). Similar findings were noted in patients with ischemic stroke attributable to large‐artery atherosclerosis (subdistribution hazard ratio, 0.48; 95% CI, 0.28–0.84) and in patients with other ischemic stroke subtypes (subdistribution hazard ratio, 0.64; 95% CI, 0.43–0.95) (both P<0.05). CONCLUSIONS: A mean LDL‐C <1.80 mmol/L was associated with a lower risk of major adverse cardiovascular events in Chinese patients with ischemic stroke with and without significant LAD. Further randomized trials to determine the optimal LDL‐C cutoff in stroke patients without significant atherosclerosis are warranted. John Wiley and Sons Inc. 2021-08-07 /pmc/articles/PMC8475056/ /pubmed/34369170 http://dx.doi.org/10.1161/JAHA.121.021855 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Lau, Kui‐Kai
Chua, Bryan J.
Ng, Alexander
Leung, Ian Yu‐Hin
Wong, Yuen‐Kwun
Chan, Anna Ho‐Yin
Chiu, Yuen‐Kei
Chu, Ariane Xia‐Wei
Leung, William C. Y.
Tsang, Anderson Chun‐On
Teo, Kay‐Cheong
Mak, Henry Ka‐Fung
Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis
title Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis
title_full Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis
title_fullStr Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis
title_full_unstemmed Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis
title_short Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis
title_sort low‐density lipoprotein cholesterol and risk of recurrent vascular events in chinese patients with ischemic stroke with and without significant atherosclerosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475056/
https://www.ncbi.nlm.nih.gov/pubmed/34369170
http://dx.doi.org/10.1161/JAHA.121.021855
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