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Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age

CONTEXT: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. OBJECTIVE: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. DESIGN: This study included 525 healthy infants (53% girls), wh...

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Autores principales: Koljonen, Laura, Enlund-Cerullo, Maria, Hauta-alus, Helena, Holmlund-Suila, Elisa, Valkama, Saara, Rosendahl, Jenni, Andersson, Sture, Pekkinen, Minna, Mäkitie, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475199/
https://www.ncbi.nlm.nih.gov/pubmed/34214153
http://dx.doi.org/10.1210/clinem/dgab495
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author Koljonen, Laura
Enlund-Cerullo, Maria
Hauta-alus, Helena
Holmlund-Suila, Elisa
Valkama, Saara
Rosendahl, Jenni
Andersson, Sture
Pekkinen, Minna
Mäkitie, Outi
author_facet Koljonen, Laura
Enlund-Cerullo, Maria
Hauta-alus, Helena
Holmlund-Suila, Elisa
Valkama, Saara
Rosendahl, Jenni
Andersson, Sture
Pekkinen, Minna
Mäkitie, Outi
author_sort Koljonen, Laura
collection PubMed
description CONTEXT: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. OBJECTIVE: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. DESIGN: This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D(3) supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. MAIN OUTCOME MEASURES: Plasma phosphate concentrations at 12 and 24 months of age. RESULTS: Mean (SD) phosphate concentration decreased from 12 months (1.9 ± 0.15 mmol/L) to 24 months (1.6 ± 0.17 mmol/L) of age (P < 0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, serum 25-hydroxyvitamin D, intact and C-terminal fibroblast growth factor 23, mean plasma phosphate was higher in boys than girls during follow-up (P = 0.019). Phosphate concentrations were similar in the vitamin D intervention groups (P > 0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P < 0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007; 95% CI 0.003-0.011, P < 0.001). CONCLUSION: Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations.
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spelling pubmed-84751992021-09-28 Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age Koljonen, Laura Enlund-Cerullo, Maria Hauta-alus, Helena Holmlund-Suila, Elisa Valkama, Saara Rosendahl, Jenni Andersson, Sture Pekkinen, Minna Mäkitie, Outi J Clin Endocrinol Metab Clinical Research Article CONTEXT: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. OBJECTIVE: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. DESIGN: This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D(3) supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. MAIN OUTCOME MEASURES: Plasma phosphate concentrations at 12 and 24 months of age. RESULTS: Mean (SD) phosphate concentration decreased from 12 months (1.9 ± 0.15 mmol/L) to 24 months (1.6 ± 0.17 mmol/L) of age (P < 0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, serum 25-hydroxyvitamin D, intact and C-terminal fibroblast growth factor 23, mean plasma phosphate was higher in boys than girls during follow-up (P = 0.019). Phosphate concentrations were similar in the vitamin D intervention groups (P > 0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P < 0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007; 95% CI 0.003-0.011, P < 0.001). CONCLUSION: Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations. Oxford University Press 2021-07-02 /pmc/articles/PMC8475199/ /pubmed/34214153 http://dx.doi.org/10.1210/clinem/dgab495 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Koljonen, Laura
Enlund-Cerullo, Maria
Hauta-alus, Helena
Holmlund-Suila, Elisa
Valkama, Saara
Rosendahl, Jenni
Andersson, Sture
Pekkinen, Minna
Mäkitie, Outi
Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
title Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
title_full Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
title_fullStr Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
title_full_unstemmed Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
title_short Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
title_sort phosphate concentrations and modifying factors in healthy children from 12 to 24 months of age
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475199/
https://www.ncbi.nlm.nih.gov/pubmed/34214153
http://dx.doi.org/10.1210/clinem/dgab495
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