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Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age
CONTEXT: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. OBJECTIVE: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. DESIGN: This study included 525 healthy infants (53% girls), wh...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475199/ https://www.ncbi.nlm.nih.gov/pubmed/34214153 http://dx.doi.org/10.1210/clinem/dgab495 |
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author | Koljonen, Laura Enlund-Cerullo, Maria Hauta-alus, Helena Holmlund-Suila, Elisa Valkama, Saara Rosendahl, Jenni Andersson, Sture Pekkinen, Minna Mäkitie, Outi |
author_facet | Koljonen, Laura Enlund-Cerullo, Maria Hauta-alus, Helena Holmlund-Suila, Elisa Valkama, Saara Rosendahl, Jenni Andersson, Sture Pekkinen, Minna Mäkitie, Outi |
author_sort | Koljonen, Laura |
collection | PubMed |
description | CONTEXT: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. OBJECTIVE: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. DESIGN: This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D(3) supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. MAIN OUTCOME MEASURES: Plasma phosphate concentrations at 12 and 24 months of age. RESULTS: Mean (SD) phosphate concentration decreased from 12 months (1.9 ± 0.15 mmol/L) to 24 months (1.6 ± 0.17 mmol/L) of age (P < 0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, serum 25-hydroxyvitamin D, intact and C-terminal fibroblast growth factor 23, mean plasma phosphate was higher in boys than girls during follow-up (P = 0.019). Phosphate concentrations were similar in the vitamin D intervention groups (P > 0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P < 0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007; 95% CI 0.003-0.011, P < 0.001). CONCLUSION: Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations. |
format | Online Article Text |
id | pubmed-8475199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84751992021-09-28 Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age Koljonen, Laura Enlund-Cerullo, Maria Hauta-alus, Helena Holmlund-Suila, Elisa Valkama, Saara Rosendahl, Jenni Andersson, Sture Pekkinen, Minna Mäkitie, Outi J Clin Endocrinol Metab Clinical Research Article CONTEXT: Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. OBJECTIVE: To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. DESIGN: This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention trial and received daily vitamin D(3) supplementation of either 10 or 30 μg from age 2 weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. MAIN OUTCOME MEASURES: Plasma phosphate concentrations at 12 and 24 months of age. RESULTS: Mean (SD) phosphate concentration decreased from 12 months (1.9 ± 0.15 mmol/L) to 24 months (1.6 ± 0.17 mmol/L) of age (P < 0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, serum 25-hydroxyvitamin D, intact and C-terminal fibroblast growth factor 23, mean plasma phosphate was higher in boys than girls during follow-up (P = 0.019). Phosphate concentrations were similar in the vitamin D intervention groups (P > 0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005; 95% CI, 0.004-0.009 and 0.002-0.008; P < 0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007; 95% CI 0.003-0.011, P < 0.001). CONCLUSION: Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations. Oxford University Press 2021-07-02 /pmc/articles/PMC8475199/ /pubmed/34214153 http://dx.doi.org/10.1210/clinem/dgab495 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Article Koljonen, Laura Enlund-Cerullo, Maria Hauta-alus, Helena Holmlund-Suila, Elisa Valkama, Saara Rosendahl, Jenni Andersson, Sture Pekkinen, Minna Mäkitie, Outi Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age |
title | Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age |
title_full | Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age |
title_fullStr | Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age |
title_full_unstemmed | Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age |
title_short | Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age |
title_sort | phosphate concentrations and modifying factors in healthy children from 12 to 24 months of age |
topic | Clinical Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475199/ https://www.ncbi.nlm.nih.gov/pubmed/34214153 http://dx.doi.org/10.1210/clinem/dgab495 |
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