Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation

GPCRs (G-protein coupled receptors) are the largest family of drug targets and share a conserved structure. Binding sites are unknown for many important GPCR ligands due to the difficulties of GPCR recombinant expression, biochemistry, and crystallography. We describe our approach, ConDockSite, for...

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Detalles Bibliográficos
Autores principales: Vidad, Ashley Ryan, Macaspac, Stephen, Ng, Ho Leung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475542/
https://www.ncbi.nlm.nih.gov/pubmed/34631323
http://dx.doi.org/10.7717/peerj.12219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475542/
https://www.ncbi.nlm.nih.gov/pubmed/34631323
http://dx.doi.org/10.7717/peerj.12219

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