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nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Alphaviruses have positive-strand RNA genomes containing two open reading frames (ORFs). The first ORF encodes the nonstructural (ns) polyproteins P123 and P1234 that act as precursors for the subunits of the viral RNA replicase (nsP1 to nsP4). Processing of P1234 leads to the formation of a negativ...

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Detalles Bibliográficos
Autores principales:	Lello, Laura Sandra, Bartholomeeusen, Koen, Wang, Sainan, Coppens, Sandra, Fragkoudis, Rennos, Alphey, Luke, Ariën, Kevin K., Merits, Andres, Utt, Age
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475546/ https://www.ncbi.nlm.nih.gov/pubmed/34319783 http://dx.doi.org/10.1128/JVI.00355-21

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