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Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism

Inborn errors of metabolism (IEMs) represent a complex system model, in need of a shift of approach exploring the main factors mediating the regulation of the system, internal or external and overcoming the traditional concept of biochemical and genetic defects. In this context, among the establishe...

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Autores principales: Montanari, Chiara, Parolisi, Sara, Borghi, Elisa, Putignani, Lorenza, Bassanini, Giulia, Zuvadelli, Juri, Bonfanti, Cristina, Tummolo, Albina, Dionisi Vici, Carlo, Biasucci, Giacomo, Burlina, Alberto, Carbone, Maria Teresa, Verduci, Elvira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475650/
https://www.ncbi.nlm.nih.gov/pubmed/34588993
http://dx.doi.org/10.3389/fphys.2021.716520
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author Montanari, Chiara
Parolisi, Sara
Borghi, Elisa
Putignani, Lorenza
Bassanini, Giulia
Zuvadelli, Juri
Bonfanti, Cristina
Tummolo, Albina
Dionisi Vici, Carlo
Biasucci, Giacomo
Burlina, Alberto
Carbone, Maria Teresa
Verduci, Elvira
author_facet Montanari, Chiara
Parolisi, Sara
Borghi, Elisa
Putignani, Lorenza
Bassanini, Giulia
Zuvadelli, Juri
Bonfanti, Cristina
Tummolo, Albina
Dionisi Vici, Carlo
Biasucci, Giacomo
Burlina, Alberto
Carbone, Maria Teresa
Verduci, Elvira
author_sort Montanari, Chiara
collection PubMed
description Inborn errors of metabolism (IEMs) represent a complex system model, in need of a shift of approach exploring the main factors mediating the regulation of the system, internal or external and overcoming the traditional concept of biochemical and genetic defects. In this context, among the established factors influencing the metabolic flux, i.e., diet, lifestyle, antibiotics, xenobiotics, infectious agents, also the individual gut microbiota should be considered. A healthy gut microbiota contributes in maintaining human health by providing unique metabolic functions to the human host. Many patients with IEMs are on special diets, the main treatment for these diseases. Hence, IEMs represent a good model to evaluate how specific dietary patterns, in terms of macronutrients composition and quality of nutrients, can be related to a characteristic microbiota associated with a specific clinical phenotype (“enterophenotype”). In the present review, we aim at reporting the possible links existing between dysbiosis, a condition reported in IEMs patients, and a pro-inflammatory status, through an altered “gut-liver” cross-talk network and a major oxidative stress, with a repercussion on the health status of the patient, increasing the risk of non-communicable diseases (NCDs). On this basis, more attention should be paid to the nutritional status assessment and the clinical and biochemical signs of possible onset of comorbidities, with the goal of improving the long-term wellbeing in IEMs. A balanced intestinal ecosystem has been shown to positively contribute to patient health and its perturbation may influence the clinical spectrum of individuals with IEMs. For this, reaching eubiosis through the improvement of the quality of dietary products and mixtures, the use of pre-, pro- and postbiotics, could represent both a preventive and therapeutic strategy in these complex diseases.
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spelling pubmed-84756502021-09-28 Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism Montanari, Chiara Parolisi, Sara Borghi, Elisa Putignani, Lorenza Bassanini, Giulia Zuvadelli, Juri Bonfanti, Cristina Tummolo, Albina Dionisi Vici, Carlo Biasucci, Giacomo Burlina, Alberto Carbone, Maria Teresa Verduci, Elvira Front Physiol Physiology Inborn errors of metabolism (IEMs) represent a complex system model, in need of a shift of approach exploring the main factors mediating the regulation of the system, internal or external and overcoming the traditional concept of biochemical and genetic defects. In this context, among the established factors influencing the metabolic flux, i.e., diet, lifestyle, antibiotics, xenobiotics, infectious agents, also the individual gut microbiota should be considered. A healthy gut microbiota contributes in maintaining human health by providing unique metabolic functions to the human host. Many patients with IEMs are on special diets, the main treatment for these diseases. Hence, IEMs represent a good model to evaluate how specific dietary patterns, in terms of macronutrients composition and quality of nutrients, can be related to a characteristic microbiota associated with a specific clinical phenotype (“enterophenotype”). In the present review, we aim at reporting the possible links existing between dysbiosis, a condition reported in IEMs patients, and a pro-inflammatory status, through an altered “gut-liver” cross-talk network and a major oxidative stress, with a repercussion on the health status of the patient, increasing the risk of non-communicable diseases (NCDs). On this basis, more attention should be paid to the nutritional status assessment and the clinical and biochemical signs of possible onset of comorbidities, with the goal of improving the long-term wellbeing in IEMs. A balanced intestinal ecosystem has been shown to positively contribute to patient health and its perturbation may influence the clinical spectrum of individuals with IEMs. For this, reaching eubiosis through the improvement of the quality of dietary products and mixtures, the use of pre-, pro- and postbiotics, could represent both a preventive and therapeutic strategy in these complex diseases. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8475650/ /pubmed/34588993 http://dx.doi.org/10.3389/fphys.2021.716520 Text en Copyright © 2021 Montanari, Parolisi, Borghi, Putignani, Bassanini, Zuvadelli, Bonfanti, Tummolo, Dionisi Vici, Biasucci, Burlina, Carbone and Verduci. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Montanari, Chiara
Parolisi, Sara
Borghi, Elisa
Putignani, Lorenza
Bassanini, Giulia
Zuvadelli, Juri
Bonfanti, Cristina
Tummolo, Albina
Dionisi Vici, Carlo
Biasucci, Giacomo
Burlina, Alberto
Carbone, Maria Teresa
Verduci, Elvira
Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism
title Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism
title_full Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism
title_fullStr Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism
title_full_unstemmed Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism
title_short Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism
title_sort dysbiosis, host metabolism, and non-communicable diseases: trialogue in the inborn errors of metabolism
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475650/
https://www.ncbi.nlm.nih.gov/pubmed/34588993
http://dx.doi.org/10.3389/fphys.2021.716520
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