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National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?

BACKGROUND: It is unclear whether the recent increase in the number of heart transplants performed annually in the United States is only because of higher availability of donors and if it affected recipients’ survival. METHODS AND RESULTS: We examined characteristics of donors and recipients from 20...

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Autores principales: Dharmavaram, Naga, Hess, Timothy, Jaeger, Heather, Smith, Jason, Hermsen, Joshua, Murray, David, Dhingra, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475695/
https://www.ncbi.nlm.nih.gov/pubmed/34315285
http://dx.doi.org/10.1161/JAHA.120.019655
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author Dharmavaram, Naga
Hess, Timothy
Jaeger, Heather
Smith, Jason
Hermsen, Joshua
Murray, David
Dhingra, Ravi
author_facet Dharmavaram, Naga
Hess, Timothy
Jaeger, Heather
Smith, Jason
Hermsen, Joshua
Murray, David
Dhingra, Ravi
author_sort Dharmavaram, Naga
collection PubMed
description BACKGROUND: It is unclear whether the recent increase in the number of heart transplants performed annually in the United States is only because of higher availability of donors and if it affected recipients’ survival. METHODS AND RESULTS: We examined characteristics of donors and recipients from 2008 to 2012 (n=11 654) and 2013 to 2017 (n=14 556) and compared them with 2003 to 2007 (n=10 869). Cox models examined 30‐day and 1‐year risk of recipients’ death post transplant. From 2013 to 2017, there was an increase in the number of transplanted hearts and number of donor offers but an overall decline in the ratio of hearts transplanted to available donors. Donors between 2013 and 2017 were older, heavier, more hypertensive, diabetic, and likely to have abused illicit drugs compared with previous years. Drug overdose and hepatitis C positive donors were additional contributors to donor risk in recent years. In Cox models, risk of death post transplant between 2013 and 2017 was 15% lower at 30 days (hazard ratio [HR] 0.85; 95% CI, 0.74–0.98) and 21% lower at 1 year (HR, 0.79; 95% CI, 0.73–0.87) and between 2008 and 2012 was 9% lower at 30 days (HR, 0.91; 95% CI, 0.79–1.05) and 14% lower at 1 year (HR, 0.86; 95% CI, 0.79–0.94) compared with 2003 to 2007. CONCLUSIONS: Despite a substantial increase in heart donor offers in recent years, the ratio of transplants performed to available donors has decreased. Even though hearts from donors who are older, more hypertensive, and have diabetes mellitus are being used, overall recipient survival continues to improve. Broader acceptance of drug overdose and hepatitis C positive donors may increase the number and percentage of heart transplants further without jeopardizing short‐term outcomes.
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spelling pubmed-84756952021-10-01 National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts? Dharmavaram, Naga Hess, Timothy Jaeger, Heather Smith, Jason Hermsen, Joshua Murray, David Dhingra, Ravi J Am Heart Assoc Original Research BACKGROUND: It is unclear whether the recent increase in the number of heart transplants performed annually in the United States is only because of higher availability of donors and if it affected recipients’ survival. METHODS AND RESULTS: We examined characteristics of donors and recipients from 2008 to 2012 (n=11 654) and 2013 to 2017 (n=14 556) and compared them with 2003 to 2007 (n=10 869). Cox models examined 30‐day and 1‐year risk of recipients’ death post transplant. From 2013 to 2017, there was an increase in the number of transplanted hearts and number of donor offers but an overall decline in the ratio of hearts transplanted to available donors. Donors between 2013 and 2017 were older, heavier, more hypertensive, diabetic, and likely to have abused illicit drugs compared with previous years. Drug overdose and hepatitis C positive donors were additional contributors to donor risk in recent years. In Cox models, risk of death post transplant between 2013 and 2017 was 15% lower at 30 days (hazard ratio [HR] 0.85; 95% CI, 0.74–0.98) and 21% lower at 1 year (HR, 0.79; 95% CI, 0.73–0.87) and between 2008 and 2012 was 9% lower at 30 days (HR, 0.91; 95% CI, 0.79–1.05) and 14% lower at 1 year (HR, 0.86; 95% CI, 0.79–0.94) compared with 2003 to 2007. CONCLUSIONS: Despite a substantial increase in heart donor offers in recent years, the ratio of transplants performed to available donors has decreased. Even though hearts from donors who are older, more hypertensive, and have diabetes mellitus are being used, overall recipient survival continues to improve. Broader acceptance of drug overdose and hepatitis C positive donors may increase the number and percentage of heart transplants further without jeopardizing short‐term outcomes. John Wiley and Sons Inc. 2021-07-28 /pmc/articles/PMC8475695/ /pubmed/34315285 http://dx.doi.org/10.1161/JAHA.120.019655 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Dharmavaram, Naga
Hess, Timothy
Jaeger, Heather
Smith, Jason
Hermsen, Joshua
Murray, David
Dhingra, Ravi
National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?
title National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?
title_full National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?
title_fullStr National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?
title_full_unstemmed National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?
title_short National Trends in Heart Donor Usage Rates: Are We Efficiently Transplanting More Hearts?
title_sort national trends in heart donor usage rates: are we efficiently transplanting more hearts?
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475695/
https://www.ncbi.nlm.nih.gov/pubmed/34315285
http://dx.doi.org/10.1161/JAHA.120.019655
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