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Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus

AIMS: To evaluate the impact of peripheral neuropathy on bone health in people with type 2 diabetes mellitus (T2DM). METHODS: Participants with T2DM were grouped according to the presence of peripheral neuropathy as assessed by vibration perception threshold (VPT). Recruitment ensured groups were ba...

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Autores principales: Lasschuit, Joel Willem Johan, Greenfield, Jerry Richard, Tonks, Katherine Thuy Trang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475816/
https://www.ncbi.nlm.nih.gov/pubmed/34568958
http://dx.doi.org/10.1007/s00592-021-01803-w
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author Lasschuit, Joel Willem Johan
Greenfield, Jerry Richard
Tonks, Katherine Thuy Trang
author_facet Lasschuit, Joel Willem Johan
Greenfield, Jerry Richard
Tonks, Katherine Thuy Trang
author_sort Lasschuit, Joel Willem Johan
collection PubMed
description AIMS: To evaluate the impact of peripheral neuropathy on bone health in people with type 2 diabetes mellitus (T2DM). METHODS: Participants with T2DM were grouped according to the presence of peripheral neuropathy as assessed by vibration perception threshold (VPT). Recruitment ensured groups were balanced for age, sex and body mass index (BMI). Bone health was measured by calcaneal quantitative ultrasound (QUS) and compared between groups. Calcaneal QUS parameters were correlated across the cohort with VPT and other prespecified variables. RESULTS: Thirty-four participants (17 per group) were included with mean age 68 ± 12 years, 47% male, with median BMI 29.9 (IQR 26.9–32.7) kg/m(2). The peripheral neuropathy group had significantly lower mean Stiffness Index (87 ± 12 versus 101 ± 16, p = 0.01), Speed of Sound (1542 ± 28 versus 1574 ± 34 m/s, p < 0.01), and a trend towards lower Broadband Ultrasound Attenuation (113 ± 10 versus 120 ± 12 dB/MHz, p = 0.07). Pedal bone health asymmetry was not a significant feature in those with peripheral neuropathy. All calcaneal QUS parameters correlated negatively with VPT, although significance of the relationship with Broadband Ultrasound Attenuation was nullified if controlled for diabetes duration or time on insulin. Broadband Ultrasound Attenuation showed independent negative correlation with diabetes duration. CONCLUSIONS: People with T2DM and peripheral neuropathy have poorer bone health as measured by calcaneal QUS than those without peripheral neuropathy, independent of age, sex and BMI.
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spelling pubmed-84758162021-09-28 Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus Lasschuit, Joel Willem Johan Greenfield, Jerry Richard Tonks, Katherine Thuy Trang Acta Diabetol Original Article AIMS: To evaluate the impact of peripheral neuropathy on bone health in people with type 2 diabetes mellitus (T2DM). METHODS: Participants with T2DM were grouped according to the presence of peripheral neuropathy as assessed by vibration perception threshold (VPT). Recruitment ensured groups were balanced for age, sex and body mass index (BMI). Bone health was measured by calcaneal quantitative ultrasound (QUS) and compared between groups. Calcaneal QUS parameters were correlated across the cohort with VPT and other prespecified variables. RESULTS: Thirty-four participants (17 per group) were included with mean age 68 ± 12 years, 47% male, with median BMI 29.9 (IQR 26.9–32.7) kg/m(2). The peripheral neuropathy group had significantly lower mean Stiffness Index (87 ± 12 versus 101 ± 16, p = 0.01), Speed of Sound (1542 ± 28 versus 1574 ± 34 m/s, p < 0.01), and a trend towards lower Broadband Ultrasound Attenuation (113 ± 10 versus 120 ± 12 dB/MHz, p = 0.07). Pedal bone health asymmetry was not a significant feature in those with peripheral neuropathy. All calcaneal QUS parameters correlated negatively with VPT, although significance of the relationship with Broadband Ultrasound Attenuation was nullified if controlled for diabetes duration or time on insulin. Broadband Ultrasound Attenuation showed independent negative correlation with diabetes duration. CONCLUSIONS: People with T2DM and peripheral neuropathy have poorer bone health as measured by calcaneal QUS than those without peripheral neuropathy, independent of age, sex and BMI. Springer Milan 2021-09-26 2022 /pmc/articles/PMC8475816/ /pubmed/34568958 http://dx.doi.org/10.1007/s00592-021-01803-w Text en © Springer-Verlag Italia S.r.l., part of Springer Nature 2021, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Lasschuit, Joel Willem Johan
Greenfield, Jerry Richard
Tonks, Katherine Thuy Trang
Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
title Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
title_full Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
title_fullStr Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
title_full_unstemmed Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
title_short Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
title_sort contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475816/
https://www.ncbi.nlm.nih.gov/pubmed/34568958
http://dx.doi.org/10.1007/s00592-021-01803-w
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