Estimation and Correlation of Serum Albumin and Serum Alkaline Phosphatase Levels Between Smokers and Non-smokers With Generalized Chronic Periodontitis

Background Periodontal disease is a chronic low-grade inflammatory disease triggered by periodontal microbial interaction present in the dysbiotic biofilm and the host's immune response further leads to the destruction of the supporting periodontal apparatus, which may, in turn, lead to tooth loss. Smoking is an environmental risk factor for periodontitis, and it enhances the secretion of various enzymes from host cells, which results in the initiation and progression of periodontal disease. The albumin concentration is related to nutrition and inflammation. Alkaline phosphatase (ALP), an enzyme found in various cells of the periodontium, is considered to cause the destruction of the periodontium. The study aimed to compare the serum albumin and serum ALP levels in smokers and non-smokers with generalized chronic periodontitis. Materials and methods The cross-sectional study included a total of 60 subjects. Subjects were divided into two groups, which included non-smokers with generalized chronic periodontitis (NS+P) and smokers with generalized chronic periodontitis (S+P). Clinical parameters analyzed were plaque index, gingival index, probing pocket depth, and clinical attachment level. The serum ALP and albumin levels were analyzed using a fully automated analyzer. Results The serum ALP levels were higher in the S+P group compared to the NS+P group. Conversely, the serum albumin levels were lower in the S+P group compared to the NS+P group. Conclusion There was a significant correlation of increased serum ALP levels and decreased serum albumin levels in the S+P group compared to the NS+P group.