Cargando…

UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b

The chaperone protein Unc-93 homolog B1 (UNC93B1) regulates internalization, trafficking, and stabilization of nucleic acid-sensing Toll-like receptors (TLR) in peripheral immune cells. We sought to determine UNC93B1 expression and its functional relevance in inflammatory and injurious processes in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klammer, Markus G., Dzaye, Omar, Wallach, Thomas, Krüger, Christina, Gaessler, Dorothea, Buonfiglioli, Alice, Derkow, Katja, Kettenmann, Helmut, Brinkmann, Melanie M., Lehnardt, Seija
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475950/ https://www.ncbi.nlm.nih.gov/pubmed/34589086 http://dx.doi.org/10.3389/fimmu.2021.715774

Ejemplares similares

Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing
por: Wallach, Thomas, et al.
Publicado: (2020)

Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway
por: Rosenberger, Karen, et al.
Publicado: (2015)

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration
por: Rosenberger, Karen, et al.
Publicado: (2014)

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation
por: Derkow, Katja, et al.
Publicado: (2015)

Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease
por: Derkow, Katja, et al.
Publicado: (2018)

Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia
por: Wallach, Thomas, et al.
Publicado: (2023)

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury
por: Ifuku, Masataka, et al.
Publicado: (2020)

UNC93B1 mediates differential trafficking of endosomal TLRs
por: Lee, Bettina L, et al.
Publicado: (2013)

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
por: Brinkmann, Melanie M., et al.
Publicado: (2007)

UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii
por: Melo, Mariane B., et al.
Publicado: (2010)

Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases
por: Harris, Katharine G., et al.
Publicado: (2015)

Release from Unc93b1 reinforces the compartmentalized activation of select TLRs
por: Majer, Olivia, et al.
Publicado: (2019)

The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis
por: an Haack, Ira, et al.
Publicado: (2015)

Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity
por: Majer, Olivia, et al.
Publicado: (2019)

IRF7 and UNC93B1 variants in an infant with recurrent herpes simplex virus infection
por: Tucker, Megan H., et al.
Publicado: (2023)

UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling
por: Itoh, Hiroki, et al.
Publicado: (2011)

N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling
por: Song, Hyun-Sup, et al.
Publicado: (2022)

Expression of Toll-Like Receptors in the Developing Brain
por: Kaul, David, et al.
Publicado: (2012)

Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response
por: Fukui, Ryutaro, et al.
Publicado: (2012)

UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection
por: Crane, Meredith J., et al.
Publicado: (2012)

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells
por: Maschalidi, Sophia, et al.
Publicado: (2017)

The Signal Peptide and Chaperone UNC93B1 Both Influence TLR8 Ectodomain Intracellular Endosomal Localization
por: Ao, Da, et al.
Publicado: (2021)

Structure-aware machine learning identifies microRNAs operating as Toll-like receptor 7/8 ligands
por: Raden, Martin, et al.
Publicado: (2021)

Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation
por: Uchino, Kaori, et al.
Publicado: (2021)

Variants Affecting the C-Terminal Tail of UNC93B1 Are Not a Common Risk Factor for Systemic Lupus Erythematosus
por: Kiener, Sarah, et al.
Publicado: (2021)

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4
por: Onodi, Fanny, et al.
Publicado: (2021)

High-expression of the innate-immune related gene UNC93B1 predicts inferior outcomes in acute myeloid leukemia
por: Li, Qiaoli, et al.
Publicado: (2023)

A Missense Variant Affecting the C-Terminal Tail of UNC93B1 in Dogs with Exfoliative Cutaneous Lupus Erythematosus (ECLE)
por: Leeb, Tosso, et al.
Publicado: (2020)

SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4
por: Onodi, Fanny, et al.
Publicado: (2021)

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
por: Fukui, Ryutaro, et al.
Publicado: (2009)

Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila
por: Pooryasin, Atefeh, et al.
Publicado: (2021)

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration
por: Wallach, Thomas, et al.
Publicado: (2021)

The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice
por: Ceder, Mikaela M., et al.
Publicado: (2017)

Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10)
por: Xu, Huiyu, et al.
Publicado: (2016)

The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction
Publicado: (1992)

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases
por: Hsu, Martin, et al.
Publicado: (2021)

The mammalian trafficking chaperone protein UNC93B1 maintains the ER calcium sensor STIM1 in a dimeric state primed for translocation to the ER cortex
por: Wang, Wen-An, et al.
Publicado: (2022)

Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS
por: Lacin, Haluk, et al.
Publicado: (2020)

FRI617 Targeting Unc119b For Insulin Sensitization
por: Mittal, Ayushi, et al.
Publicado: (2023)

The human homologue of unc-93 maps to chromosome 6q27 – characterisation and analysis in sporadic epithelial ovarian cancer
por: Liu, Ying, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_1lkos00a8si7udjfjgcmuj2h3e